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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 706 - 713 (8page)
- DOI
- 10.14348/molcells.2017.0225
이용수
초록· 키워드
오류제보하기
Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-?B ligand (RANKL) for their survival, proliferation, differentiation, and activation. The binding of RANKL to its receptor RANK triggers osteoclast precursors to differentiate into osteoclasts. This process depends on RANKL-RANK signaling, which is temporally regulated by various adaptor proteins and kinases. Here we summarize the current understanding of the mechanisms that regulate RANK signaling during osteoclastogenesis. In the early stage, RANK signaling is mediated by recruiting adaptor molecules such as tumor necrosis factor receptor-associated factor 6 (TRAF6), which leads to the activation of mitogen-activated protein kinases (MAPKs), and the transcription factors nuclear factor-?B (NF-?B) and activator protein-1 (AP-1). Activated NF-?B induces the nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), which is the key osteoclastogenesis regulator. In the intermediate stage of signaling, the co-stimulatory signal induces Ca2+ oscillation via activated phospholipase C?2 (PLC?2) together with c-Fos/AP-1, wherein Ca2+ signaling facilitates the robust production of NFATc1. In the late stage of osteoclastogenesis, NFATc1 translocates into the nucleus where it induces numerous osteoclast-specific target genes that are responsible for cell fusion and function.
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등록된 정보가 없습니다.
참고문헌 (70)
참고문헌 신청
Aliprantis, A. O. / 2008 / NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism / J. Clin. Invest 118:3775~3789
Asagiri, M. / 2007 / The molecular understanding of osteoclast differentiation / Bone 40:251~264
Asagiri, M. / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis / J. Exp. Med 202:1261~1269
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Cella, M. / 2003 / Impaired differentiation of osteoclasts in TREM-2-deficient individuals / J. Exp. Med 198:645~651
Asagiri, M. / 2007 / The molecular understanding of osteoclast differentiation / Bone 40:251~264
Asagiri, M. / 2005 / Autoamplification of NFATc1 expression determines its essential role in bone homeostasis / J. Exp. Med 202:1261~1269
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Cella, M. / 2003 / Impaired differentiation of osteoclasts in TREM-2-deficient individuals / J. Exp. Med 198:645~651
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