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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 65 - 74 (10page)
- DOI
- 10.14348/molcells.2015.2241
이용수
초록· 키워드
오류제보하기
Osteoclasts are unique cells responsible for the resorption of bone matrix. MicroRNAs (miRNAs) are involved in the regulation of a wide range of physiological processes. Here, we examined the role of miR-26a in RANKL-induced osteoclastogenesis. The expression of miR-26a was upregulated by RANKL at the late stage of osteoclastogenesis.
Ectopic expression of an miR-26a mimic in osteoclast precursor cells attenuated osteoclast formation, actin-ring formation, and bone resorption by suppressing the expression of connective tissue growth factor/CCN family 2 (CTGF/ CCN2), which can promote osteoclast formation via upregulation of dendritic cell-specific transmembrane protein (DC-STAMP). On the other hand, overexpression of miR-26a inhibitor enhanced RANKL-induced osteoclast formation and function as well as CTGF expression. In addition, the inhibitory effect of miR-26a on osteoclast formation and function was prevented by treatment with recombinant CTGF. Collectively, our results suggest that miR-26a modulates osteoclast formation and function through the regulation of CTGF.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Ambros, V. / 2004 / The functions of animal microRNAs / Nature 431:350~355
Asagiri, M. / 2007 / The molecular understanding of osteoclast differentiation / Bone 40:251~264
Bartel, D. P. / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Cheng, P. / 2013 / miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B / J. Bone Miner. Res 28:1180~1190
Asagiri, M. / 2007 / The molecular understanding of osteoclast differentiation / Bone 40:251~264
Bartel, D. P. / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Cheng, P. / 2013 / miR-148a regulates osteoclastogenesis by targeting V-maf musculoaponeurotic fibrosarcoma oncogene homolog B / J. Bone Miner. Res 28:1180~1190
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