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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제8호
- 발행연도
- 2018.1
- 수록면
- 1,270 - 1,281 (12page)
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초록· 키워드
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Periodontal disease is triggered by the host immune response to pathogens in the microbial biofilm. Worsening of periodontal disease destroys the tooth-supporting tissues and alveolar bone. As oral inflammation can induce systemic diseases in humans, it is important to prevent periodontal disease. In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells. LPS-upregulated inflammatory factors, such as nuclear factor kappa B p65 and interleukin-1β, were prominently reduced by CXS and XAN. In addition, RANKL-induced osteoclastic factors, such as nuclear factor of activated T-cells c1, tartrate-resistant acid phosphatase, and cathepsin K, were decreased in the presence of CXS and XAN. CXS and XAN inhibited the mitogen-activated protein kinase (MAPK)/activator protein-1 (AP-1) signaling pathway. Collectively, these results provide evidence that CXS and XAN suppress LPS-induced inflammation and RANKL-induced osteoclastogenesis by suppressing the MAPK/AP-1 pathway.
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참고문헌 (29)
참고문헌 신청
Hasan A / 2014 / A clinical guide to periodontology: pathology of periodontal disease / Br. Dent. J. 216:457~461
Paster BJ / 2006 / The breadth of bacterial diversity in the human periodontal pocket and other oral sites / Periodontol. 42:80~87
Kato H / 2014 / Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells / Arch. Oral Biol. 59:167~175
Li Q / 2012 / MAPK usage in periodontal disease progression / J. Signal Transduct. 2012:308943
김해봄 / 2018 / Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro / Journal of Microbiology and Biotechnology 28(2):190~198
Paster BJ / 2006 / The breadth of bacterial diversity in the human periodontal pocket and other oral sites / Periodontol. 42:80~87
Kato H / 2014 / Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells / Arch. Oral Biol. 59:167~175
Li Q / 2012 / MAPK usage in periodontal disease progression / J. Signal Transduct. 2012:308943
김해봄 / 2018 / Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro / Journal of Microbiology and Biotechnology 28(2):190~198
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