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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 340 - 349 (10page)
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Oleoylethanolamide (OEA), a bioactive lipid in bone, is known as an endogenous ligand for G protein-coupled receptor 119 (GPR119). Here, we explored the effects of OEA on osteoclast differentiation, function, and survival. While OEA inhibits osteoclast resorptive function by disrupting actin cytoskeleton, it does not affect receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. OEA attenuates osteoclast spreading, blocks actin ring formation, and eventually impairs bone resorption. Mechanistically, OEA inhibits Rac activation in response to macrophage colony-stimulating factor (M-CSF), but not RANKL. Furthermore, the OEA-mediated cytoskeletal disorganization is abrogated by GPR119 knockdown using small hairpin RNA (shRNA), indicating that GPR119 is pivotal for osteoclast cytoskeletal organization. In addition, OEA induces apoptosis in both control and GPR119 shRNA-transduced osteoclasts, suggesting that GPR119 is not required for osteoclast apoptosis. Collectively, our findings reveal that OEA has inhibitory effects on osteoclast function and survival of mature osteoclasts via GPR119-dependent and GPR119-independent pathways, respectively.
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참고문헌 (44)
참고문헌 신청
Akiyama, T. / 2003 / Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2family member Bim / EMBO J 22:6653~6664
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Chellaiah, M. A. / 2000 / Rho-A is critical for osteoclast podosome organization, motility, and bone resorption / J. Biol. Chem 275:11993~12002
Croke, M. / 2011 / Rac deletion in osteoclasts causes severe osteopetrosis / J. Cell Sci 124:3811~3821
Di Paola, M. / 2018 / Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice / Sci. Rep 8:14881
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Chellaiah, M. A. / 2000 / Rho-A is critical for osteoclast podosome organization, motility, and bone resorption / J. Biol. Chem 275:11993~12002
Croke, M. / 2011 / Rac deletion in osteoclasts causes severe osteopetrosis / J. Cell Sci 124:3811~3821
Di Paola, M. / 2018 / Oleoylethanolamide treatment affects gut microbiota composition and the expression of intestinal cytokines in Peyer’s patches of mice / Sci. Rep 8:14881
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