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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 752 - 760 (9page)
- DOI
- 10.14348/molcells.2017.0098
이용수
초록· 키워드
오류제보하기
A2B adenosine receptor (A2BAR) is known to be the regulator of bone homeostasis, but its regulatory mechanisms in osteoclast formation are less well-defined. Here, we demonstrate the effect of A2BAR stimulation on osteoclast differentiation and activity by RANKL. A2BAR was expressed in bone marrow-derived monocyte/macrophage (BMM) and RANKL increased A2BAR expression during osteoclastogenesis. A2BAR stimulation with its specific agonist BAY 60-6583 was sufficient to inhibit the activation of ERK1/2, p38 MAP kinas-es and NF-?B by RANKL as well as it abrogated cell-cell fusion in the late stage of osteoclast differentiation. Stimulation of A2BAR suppressed the expression of osteoclast marker genes, such as c-Fos, TRAP, Cathepsin-K and NFATc1, induced by RANKL, and transcriptional activity of NFATc1 was also inhibited by stimulation of A2BAR. A2BAR stimulation caused a notable reduction in the expression of Atp6v0d2 and DC-STAMP related to cell-cell fusion of osteoclasts. Especially, a decrease in bone resorption activity through suppression of actin ring formation by A2BAR stimulation was observed. Taken together, these results suggest that A2BAR stimulation inhibits the activation of ERK1/2, p38 and NF-?B by RANKL, which suppresses the induction of osteoclast marker genes, thus contributing to the decrease in osteoclast cell-cell fusion and bone resorption activity.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Bowler, W. B. / 2001 / Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling / Bone 28:507~512
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Burgess, T. L. / 1999 / The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts / J. Cell Biol 145:527~538
Carroll, S. H. / 2012 / A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo / J. Biol. Chem 287:15718~15727
Chen, J. F. / 2013 / Adenosine receptors as drug targets--what are the challenges? / Nat. Rev. Drug Discov 12:265~286
Boyle, W. J. / 2003 / Osteoclast differentiation and activation / Nature 423:337~342
Burgess, T. L. / 1999 / The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts / J. Cell Biol 145:527~538
Carroll, S. H. / 2012 / A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo / J. Biol. Chem 287:15718~15727
Chen, J. F. / 2013 / Adenosine receptors as drug targets--what are the challenges? / Nat. Rev. Drug Discov 12:265~286
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