지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.10
- 수록면
- 749 - 760 (12page)
이용수
초록· 키워드
오류제보하기
Osteoclast generation from monocyte/macrophage lineage precursor cells needs to be tightly regulated to maintain bone homeostasis and is frequently over-activated in inflammatory conditions. PARK2, a protein associated with Parkinson’s disease, plays an important role in mitophagy via its ubiquitin ligase function. In this study, we investigated whether PARK2 is involved in osteoclastogenesis. PARK2 expression was found to be increased during the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. PARK2 gene silencing with siRNA significantly reduced osteoclastogenesis induced by RANKL, LPS (lipopolysaccharide), TNFα (tumor necrosis factor α), and IL-1β (interleukin-1β). On the other hand, overexpression of PARK2 promoted osteoclastogenesis. This regulation of osteoclastogenesis by PARK2 was mediated by IKK (inhibitory κB kinase) and NF-κB activation while MAPK (mitogen-activated protein kinases) activation was not involved. Additionally, administration of PARK2 siRNA significantly reduced osteoclastogenesis and bone loss in an in vivo model of inflammatory bone erosion. Taken together, this study establishes a novel role for PARK2 as a positive regulator in osteoclast differentiation and inflammatory bone destruction.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The Inactivation of ERK1/2, p38 and NF-kB Is Involved in the Down-Regulation of Osteoclastogenesis and Function by A2B Adenosine Receptor Stimulation
Molecules and Cells
2017 .10
-
Antimicrobial agents, outer membrane assembly machine, lipoprotein, lipopolysaccharide, outer membrane β-barrel protein, phospholipid
Journal of Microbiology and Biotechnology
2019 .01
-
MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation
Molecules and Cells
2015 .01
-
Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity
Molecules and Cells
2016 .04
-
Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation
Molecules and Cells
2017 .10
-
국립공원의 구역 변천 및 용도지구 설정을 기반으로 한 해상 · 해안형 국립공원 관리개선방안에 대한 기초 연구
한국환경과학회지
2020 .02
-
ST5 Positively Regulates Osteoclastogenesis via Src/Syk/calcium Signaling Pathways
Molecules and Cells
2019 .01
-
Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Resorption
Molecules and Cells
2018 .03
-
청장년층과 노년층의 공원환경 인식 및 만족 요인 차이 분석
한국환경과학회지
2020 .02
-
Enterococcus faecalis induces Inflammatory Bone Diseases by Enhancing Osteoclast Differentiation
한국미생물학회 학술대회논문집
2015 .04
-
Augmented Osteoclastogenesis from Committed Osteoclast Precursors by Periodontopathic Bacteria Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis
한국미생물·생명공학회지
2016 .12
-
장기미집행 공원 부지를 활용한 주거 개발 방안
한국주거학회 학술대회논문집
2018 .04
-
도심 내 소공원 유지관리 실태에 관한 기초연구 - 김포시 소공원을 중심으로 -
한국환경과학회지
2021 .11
-
Label-free Noninvasive Characterization of Osteoclast Differentiation Using Raman Spectroscopy Coupled with Multivariate Analysis
Current Optics and Photonics
2017 .08
-
Calcium-Phosphate Crystals Promote RANKL Expression via the Downregulation of DUSP1
Molecules and Cells
2019 .01
-
Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro
Journal of Microbiology and Biotechnology
2018 .01
-
Inhibitory Effect of Biotransformed- Fucoidan on the Differentiation of Osteoclasts Induced by Receptor for Activation of Nuclear Factor-κB Ligand
Journal of Microbiology and Biotechnology
2022 .08
-
Inhibitory Effects of Curcuma xanthorrhiza Supercritical Extract and Xanthorrhizol on LPS-Induced Inflammation in HGF-1 Cells and RANKL-Induced Osteoclastogenesis in RAW264.7 Cells
Journal of Microbiology and Biotechnology
2018 .01
-
갈색거저리 유충 에탄올 추출물이 RANKL에 의해 유도되는 파골세포 분화에 미치는 영향
생명과학회지
2020 .11
-
Anyang Citizens’ Awareness of the Effects of City Parks on City Dwellers
한국환경과학회지
2019 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0