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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 557 - 562 (6page)
- DOI
- 10.4014/mbl.1608.08010
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초록· 키워드
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Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis are gram-negative bacteria frequently found in lesions from patients with periodontitis manifesting alveolar bone loss. Lipopolysaccharides are a major virulence factor of gram-negative bacteria. Bone resorption is known to be regulated by bacteria and their virulence factors. In the present study, we investigated the effects of A. actinomycetemcomitans and P. gingivalis on bone resorption. Heat-killed A. actinomycetemcomitans (HKAa) and heatkilled P. gingivalis (HKPg) induced bone loss in the femurs of mice after intraperitoneal administration. HKAa and HKPg augmented the differentiation of committed osteoclast precursors into osteoclasts, while they inhibited the differentiation of bone marrow-derived macrophages into osteoclasts. Concordant with the effects of the heat-killed whole cells, LPS purified from A. actinomycetemcomitans and P. gingivalis also augmented osteoclast differentiation from committed osteoclast precursors but attenuated it from bone marrow-derived macrophages. Taken together, these results suggest that the whole cells and lipopolysaccharides of A. actinomycetemcomitans and P. gingivalis induce the differentiation of committed osteoclast precursors into osteoclasts, potentially contributing to bone resorption in vivo.
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참고문헌 (24)
참고문헌 신청
Arai F / 1999 / Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappaB (RANK) receptors / J. Exp. Med 190:1741~1754
Feng X / 2011 / Disorders of bone remodeling / Annu. Rev. Pathol 6:121~145
Flemmig TF. / 1999 / Periodontitis / Ann. Periodontol 4:32~38
Irfan UM / 2001 / Epidemiology of periodontal disease: a review and clinical perspectives / J. Int. Acad Periodontol 3:14~21
Kang J / 2012 / Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis / Infect. Immun 80:2247~2256
Feng X / 2011 / Disorders of bone remodeling / Annu. Rev. Pathol 6:121~145
Flemmig TF. / 1999 / Periodontitis / Ann. Periodontol 4:32~38
Irfan UM / 2001 / Epidemiology of periodontal disease: a review and clinical perspectives / J. Int. Acad Periodontol 3:14~21
Kang J / 2012 / Aggregatibacter actinomycetemcomitans infection enhances apoptosis in vivo through a caspase-3-dependent mechanism in experimental periodontitis / Infect. Immun 80:2247~2256
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