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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 326 - 331 (6page)
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Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat em-bryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble neural cel adhesion molecule (NCAM) to these precursor cels reduced cel proliferation in a dose dependent manner and enhanced the induction of precursor cels' diferentiation to the neuronal line-age. Given these findings that NCAM induces the diferentiation of hippocampal precursor cels, we investigated posible efects of NCAM on the ex-pression of basic helix-loop-helix (bHLH) tran-scription factors during the diferentiation. Sol-uble NCAM upregulated the transcription of bHLH decreased HES5. Western blot analysis showed that NCAM increased the expresion levels of CaMKII, p-MAPK, GluR1 and NR1 but decreased p-STAT3. These results suport a role for NCAM in the inhibition of proliferation and the induction of neural diferentiation of hippocampal neural pre-cursor cels, and act as developmental regulators of the bHLH families, ultimately leading to the generation of glutamatergic neural cel types in the diferentiation of hippocampal precursor cels.
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