지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Chronic eosinophilic leukemia (CEL) is a myeloproliferative disease with an increased number of mature eosinophils and their precursors, which results in infiltration into organs and organ enlargement. The main cause of this disease is the overexpression of tyrosine kinase. However, there is a need for alternative medication, because some patients are resistant to imatinib, which is a tyrosine kinase inhibitor for leukemia. Many studies have indicated that S100A8 and splicing factor proline and glutamine-rich (SFPQ) function as initiation signals of apoptosis in CEL cells. We reviewed structural studies on CEL cells related to S100A8 and SFPQ. Particularly, this review highlighted microscopic results for the study of S100A8 and SFPQ in CEL cells.
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참고문헌 (24)
참고문헌 신청
Asakura M / 2016 / Vildagliptin and its metabolite M20.7 induce the expression of S100A8 and S100A9 in human hepatoma HepG2 and leukemia HL-60 cells / Sci Rep 6 : 35633 ~
Bresnick A R / 2015 / S100 proteins in cancer / Nat Rev Cancer 15 : 96 ~ 109
Chakraborty P / 2015 / Vesicular location and transport of S100A8 and S100A9 proteins in monocytoid cells / PLoS One 10 : e0145217 ~
Demoulin J B / 2012 / Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis / Am J Blood Res 2 : 44 ~ 56
Donato R / 2013 / Functions of S100 proteins / Curr Mol Med 13 : 24 ~ 57
Bresnick A R / 2015 / S100 proteins in cancer / Nat Rev Cancer 15 : 96 ~ 109
Chakraborty P / 2015 / Vesicular location and transport of S100A8 and S100A9 proteins in monocytoid cells / PLoS One 10 : e0145217 ~
Demoulin J B / 2012 / Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis / Am J Blood Res 2 : 44 ~ 56
Donato R / 2013 / Functions of S100 proteins / Curr Mol Med 13 : 24 ~ 57
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