지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 732 - 738 (7page)
이용수
초록· 키워드
오류제보하기
It has been shown that neural cell adhesion molecule (NCAM)-induced neuronal differentiation is extra-cellular signal-regulated kinase (ERK)-dependent. However, an involvement of the mitogen activated protein kinase (MAPK) kinase (MEK), an upstream kinase of ERK, has not been directly demonstrated in this process. Therefore, we investigated whether the MEK1 plays a critical role in the NCAM-induced neuronal differentiation of hippocampal neural progenitor cells (NPCs). NPCs were transiently transfected with expression plasmids encoding activated or dominant negative (DN) forms of MEK1. The expression of DN MEK1 inhibited neuronal phenotype acquisition and soluble NCAM rescued the defect in the neuronal phenotype acquisition in DN-MEK1-transfected cells, suggesting that NCAM might contribute to the neuronal differentiation via distinct, parallel pathways including the MEK pathway. In cells expressing wild type MEK1 or constitutively active MEK1 on the other hand, the percentage of cells positive for β-tubulin type III (Tuj1), a marker for early postmitotic neurons, was higher than seen in vector-transfected cells. These results suggest that the activation of MEK1 is required for obtaining neuronal phenotype in NPCs.
목차
등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
/ / Overexpression of mitogen-activated protein kinase kinase and its mutants in NIH 3T3 cells Evidence that MAPKK involvement in cellular proliferation is regulated by phos
/ 1993 / Identification and characterization of a nerve growth factor stimulated mitogen- activated protein kinase activator in PC12 cells 268 : 7055 ~ 63
/ 1994 / Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells 77 : 841 ~ 52
/ 1994 / NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice 127 : 825 ~ 33
/ 1995 / RAS signalling is abnormal in a c-raf1 MEK1 double mutant 15 : 5113 ~ 5122
/ 1993 / Identification and characterization of a nerve growth factor stimulated mitogen- activated protein kinase activator in PC12 cells 268 : 7055 ~ 63
/ 1994 / Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH3T3 cells 77 : 841 ~ 52
/ 1994 / NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice 127 : 825 ~ 33
/ 1995 / RAS signalling is abnormal in a c-raf1 MEK1 double mutant 15 : 5113 ~ 5122
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Neural cell adhesion molecule(NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
Experimental and Molecular Medicine
2002 .01
-
Yeast내에서 MEK1 융합 단백질 발현 및 Lethal Factor 활성 검증
미생물학회지
2006 .09
-
CD137 induces adhesion and cytokine production in human monocytic THP-1cells
Experimental and Molecular Medicine
2005 .01
-
Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines
Experimental and Molecular Medicine
2006 .01
-
Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence
Experimental and Molecular Medicine
2002 .01
-
불로초의 β-Glucan에 의한 Dectin-1 발현 유도와 세포 내 신호전달
한국균학회지
2018 .01
-
A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells
Experimental and Molecular Medicine
2012 .01
-
Increase of Cdk5 and p35 during Retinoic Acid-Induced Neuronal Differentiation of SK-N-BE(2)C cells
한국생물물리학회 학술발표회
2002 .01
-
Sodium tanshinone IIA sulfonate depresses angiotensin IIinducedcardiomyocyte hypertrophy through MEK/ERKpathway
Experimental and Molecular Medicine
2007 .01
-
Transcriptional Profiling in Neuronal Differentiation of Stem Cells
한국유전체학회 Conference
2003 .01
-
Surface Oxygen Group의 생성이 benzene 및 MEK 흡착 특성에 미치는 영향
한국대기환경학회 학술대회논문집
2005 .11
-
Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway
Experimental and Molecular Medicine
2009 .01
-
Butyrate-induced differentiation of PC12 cells to chromaffin cells involves cell adhesion and induction of extracellular proteins and cell adhesion proteins
Animal cells and systems
2010 .01
-
Astaxanthin Inhibits H2O2-Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways
Journal of Microbiology and Biotechnology
2009 .01
-
생쥐 뇌세포에 알코올이 미치는 영향
대한임상검사과학회지
2015 .01
-
Differentiation of human gingival mesenchymal stem cells into neuronal lineages in 3D bioconjugated injectable protein hydrogel construct for the management of neuronal disorder
Experimental and Molecular Medicine
2016 .01
-
2,2',5,5'-Tetrachlorobiphenyl Mediates Oxidative Stress-Induced Neuronal Apoptosis in Neuronal SK-N-MC Cells
한국생명과학회 학술발표회
2001 .01
-
표면산화 처리된 흡착제의 Benzene 및 MEK 흡착 특성 - HNO₃, H₂SO₄ 및 (NH₄)₂S₂O8에 의한 표면산화 -
한국대기환경학회지(국문)
2006 .02
-
Imaging neuronal cell with atomic force microscopy
한국진공학회 학술발표회초록집
2016 .08
-
Apoptosis signal-regulating kinase 1 (ASK1) is linked to neural stem cell differentiation after ischemic brain injury
Experimental and Molecular Medicine
2013 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0