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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 38 - 45 (8page)
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Phospholipase D (PLD) plays an important role as an efector in a variety of physiological pro-cesses that reveal it to be a member of the signal transducing phospholipases. Recently, PLD2 was reported as a necessary intermediate in preventing poxia in rat pheochromocytoma (PC12) cells. The data presented here show that both PLD isozy-mes, PLD1 and PLD2 are also required in at-tenuating glutamate-induced cel death in PC12 cels. Treatment of PC12 cels with glutamate resulted in induction of apoptosis in these cels, which is accompanied by decreased PLD activity and increased ceramide concentration. Incubation of PC12 cels with exogenous C6-ceramide showed a time-dependent decrease of PLD activity. When cDNAs of PLD1 and PLD2 were transfected into or PLD2 resulted in inhibition of glutamate-in-duced apoptotic cel death. These data indicate that both PLD1 and PLD2 play a protective role against glutamate-induced cell death in PC12 cells.
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