지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 438 - 447 (10page)
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CD99 is a 32-kDa cell surface molecule present on thymocytes, peripheral T cels, many other he-matopoietic stem cells and somatic cells were implicated in cell-cell adhesion and cell-activation phenomena. Two major subtypes have been iden-tified so far, designated CD99 type I and type I. We have investigated the corelation between the degre of neural diferentiation and the expres-sion of CD99 subtypes in three diferentially dif-ferentiated cel lines such as CADO-ES1, RD-ES, and SH-N-SY5Y, in order of diferentiation. In ad-ition, we induced diferentiation of the RD-ES cel line by N6,2'-dibutyryl-cAMP (db-cAMP). Six days after treatment with db-cAMP, RD-ES cel line has changed its morphology from uniform round cels to cells with neurites, and initially CD9 type I-overexpressed RD-ES cells showed significant down-regulation of CD99 type II, whereas CD9 type I expression remained constant. When RD- ES cels were transfected with the cDNA encoding for CD99 type I-green fluorescence protein (GFP) and type II-GFP, CD9 type II transfected RD-ES cel line remained unchanged with morphology of undifferentiated form. Our data sugest that CD9 type II acts as a negative regulator in the neural diferentiation of precursor cells that might occur during nerve system development.
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