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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005
- 수록면
- 45 - 50 (6page)
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초록· 키워드
오류제보하기
Leukotriene B4 (LTB4), derived from arachidonic acid, is a potent chemotactic agent and activat-ing factor for hematopoietic cells. In adition to host defense in vivo, several eicosanoids have been reported to be involved in stem cel dif-ferentiation or proliferation. In this study, we investigated the effect of LTB4blood CD34+ hematopoietic stem cells (HSCs). LTB4 was shown to induce proliferation of HSC and exert anti-apoptotic effect on the stem cells. Blockade of interaction betwen LTB4 and its receptor enhanced self-renewal of the stem cels. Efect of LTB4 on diferentiation of CD34+ HSCs were confirmed by clonogenic asays, and in-duction of the expresion of BLT2 (the low- affinity LTB4 receptor), during the ex vivo expan-sion was confirmed by reverse transcription- 4-BLT2 inter-action is involved in the cytokine-induced dif-ferentiation and ex vivo expansion of hemato-poietic stem cells.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ / Comparison of oligonucleotide-microassay and serialanalysis of gene expression in transcript profilinganalysis of megakaryocytes derived from CD34+ cells
/ / Divergent effect of mometasone on human eosinophil andneutrophil apoptosis : 1523 ~ 34
/ / Ex vivo expansion of stem and progenitorcells in co-culture of mobilized peripheral blood CD34+ cellson human endothelium transfected with adenovectors expressingthrombop
/ / Leukotriene B4 receptor antagonist LY293111inhibits proliferation and induces apoptosis in human pancreaticcancer cells : 3232 ~ 42
/ / Leukotriene B4 stimulates Rac-ERK cascade togenerate reactive oxygen species that mediates chemotaxis 227 : 8572 ~ 8
/ / Divergent effect of mometasone on human eosinophil andneutrophil apoptosis : 1523 ~ 34
/ / Ex vivo expansion of stem and progenitorcells in co-culture of mobilized peripheral blood CD34+ cellson human endothelium transfected with adenovectors expressingthrombop
/ / Leukotriene B4 receptor antagonist LY293111inhibits proliferation and induces apoptosis in human pancreaticcancer cells : 3232 ~ 42
/ / Leukotriene B4 stimulates Rac-ERK cascade togenerate reactive oxygen species that mediates chemotaxis 227 : 8572 ~ 8
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