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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 469 - 475 (7page)
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초록· 키워드
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Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor expresed in neuronal precursors in the developing nervous system. The function of Ngn1 in neurogenesis has been shown in various aspects. In this study, we investigated the neurogenic potential of Ngn1 using neuro-blastoma cel line, F11, which could be induced to diferentiate into neurons in the presence of cAMP. To investigate the expresion of Ngn1, ex-pression vectors for the ful-length and the C- ted and their transactivation potential was verified using reporter gene containing the E-box se-quence. Overexpression of the ful-length Ngn1 induced neurite outgrowth in F1 cells in the ab-sence of cAMP. A C-terminal deletion mutant, Ngn1(1-197), inhibited neurite outgrowth induced by cAMP in F11 cells. These results indicate that the Ngn1 plays an important role in diferentiation of neuroblastoma cels and the C terminus of Ngn1 is essential for the efficient diferentiation.
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