지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 30 - 37 (8page)
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To investigate the functional role of KAI1/CD82, a metastasis suppressor for human prostate cancer, in the regulation of homotypic cel adhesion, we transfected KAI1 cDNA into DU 145 human pros-tate cancer cels and established stable transfec-tant clones with high KAI1/CD82 expression. The KAI1 transfectant cels exhibited significantly in-creased homotypic cell agregation in comparison of the KAI1 transfectants was further enhanced upon exposure to anti-CD82 antibody, suggesting that KAI1/CD82 may be involved in the intracellular signaling for the cel adhesion. Among several signal pathway inhibitors tested, PP1, an inhibitor of Src family kinases, significantly supressed ho-motypic aggregation of the KAI1 transfectant cels. Ligation of KAI1/CD82 with anti-CD82 antibody in-creased endogenous Src kinase activity of the KAI1 transfectant cels. When diferent types of src ex-KAI1-transfected DU 145 cels, kinase-negative mu-tant src transfectant cels exhibited much lower homotypic aggregation than the mock cells trans-fected with an empty vector. Moreover, homotypic aggregation of the mutant src transfectant cels was not enhanced by KAI1/CD82 ligation with anti- CD82 antibody. These results suggest that Src mediates the intracellular signaling pathway of KAI1/CD82 for the induction of homotypic adhe-sion of human prostate cancer cels.
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