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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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이 논문의 연구 히스토리 (2)
2016
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Objective. Gout is known to be associated with cardiovascular disease (CVD), and hyperhomocysteinemia is one of the risk factors for CVD. We investigated the associations between the change of serum homocysteine (Hcy) level and those of the other parameters including serum uric acid level, renal function, and cholesterol profiles in chronic gout patients with longitudinal follow-up data. Methods. Ninety-one male patients with chronic gout and 97 age-matched healthy male control subjects were included in the previous study. Among them, 33 patients with gout and 39 healthy control subjects underwent follow-up tests for Hcy levels with an average of 24.00±9.12 months in this study. Results. The follow-up data showed that gout patients had significantly higher levels of Hcy in serum than control subjects (16.75±5.43 μmol/L vs. 13.17±3.83 μmol/L, p=0.002). In gout patients, the change of serum Hcy level after follow up showed positive correlation with the change of creatinine (γ=0.442, p=0.009) and negative correlation with estimated glomerular filtration rate (eGFR; γ=−0.528, p＜0.001). However, the change of serum Hcy level did not show correlation with the changes of uric acid level or the lipid profiles. Conclusion. Serum Hcy level was elevated in gout patients compared with control subjects. The change of serum Hcy level showed negative correlation with the change of eGFR. Hyperhomocysteinemia in gout patients was associated with decreased renal function, but not with serum uric acid or lipid profiles. (J Rheum Dis 2016;23:30-36)
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참고문헌 (35)
참고문헌 신청
Puig JG / 2008 / Hyperuricemia, gout and the metabolic syndrome / Curr Opin Rheumatol 20:187~191
Kuo CF / 2010 / Gout: an independent risk factor for all-cause and cardiovascular mortality / Rheumatology (Oxford) 49:141~146
Khosla UM / 2005 / Hyperuricemia induces endothelial dysfunction / Kidney Int 67:1739~1742
Danesh J / 2000 / Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses / BMJ 321:199~204
Frosst P / 1995 / A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase / Nat Genet 10:111~113
Kuo CF / 2010 / Gout: an independent risk factor for all-cause and cardiovascular mortality / Rheumatology (Oxford) 49:141~146
Khosla UM / 2005 / Hyperuricemia induces endothelial dysfunction / Kidney Int 67:1739~1742
Danesh J / 2000 / Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses / BMJ 321:199~204
Frosst P / 1995 / A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase / Nat Genet 10:111~113
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