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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 76 - 82 (7page)
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High sensitivity C-reactive protein (hs-CRP) and homocysteine (Hcy) are associated with vascular inflammatory responses and confirmed to be associated with cardiovascular disease and metabolic syndrome. However, it is still unclear whether the combination of hs-CRP and Hcy predicts the development of metabolic syndrome. This study evaluated the combination of hs-CRP and Hcy as a predictor of metabolic syndrome in healthy adults. From January 2017 to August 2019, this study was conducted on healthy adults who were over 20 years old. They underwent a general health examination at a general hospital in the Seoul metropolitan area. High hs-CRP and Hcy levels were defined as outcome values corresponding to the 75th percentile of all the subjects. The diagnosis of metabolic syndrome applied the NCEP-ATP III criteria. hs-CRP increased the risk of developing metabolic syndrome in the fourth quartile more than in the first quartile. The probability of developing metabolic syndrome in the group with only high hs-CRP levels was 2.38 for men and 3.50 for women. The incidence of metabolic syndrome with a combination of both high hs-CRP and Hcy levels was 3.42 for men and 6.55 for women. In conclusion, this study demonstrated that the combination of high levels of serum hs-CRP and Hcy can be a predicting factor for a patient’s risk of developing metabolic syndrome.
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참고문헌 (35)
참고문헌 신청
Federico Cacciapuoti / 2017 / Hyper-homocysteinemia Inducing Hyperuricemia: What are the Mechanisms? / 대한류마티스학회지 24(3):127~130
Cho, D. Y. / 2012 / Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population / Chin Med J (Engl) 125:569~573
Chuang, C. H. / 2013 / Homocysteine and C-reactive protein as useful surrogate markers for evaluating CKD risk in adults / Kidney Blood Press Res 37:402~413
Doronzo, G. / 2005 / Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways / Thromb Haemost 94:1285~1293
Ford, E. S. / 2003 / The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey / Atherosclerosis 168:351~358
Cho, D. Y. / 2012 / Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population / Chin Med J (Engl) 125:569~573
Chuang, C. H. / 2013 / Homocysteine and C-reactive protein as useful surrogate markers for evaluating CKD risk in adults / Kidney Blood Press Res 37:402~413
Doronzo, G. / 2005 / Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways / Thromb Haemost 94:1285~1293
Ford, E. S. / 2003 / The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey / Atherosclerosis 168:351~358
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