지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 158 - 168 (11page)
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초록· 키워드
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Background: Low testosterone is associated with metabolic syndrome (MetS), and homocysteine (Hcy) is elevated in individuals with MetS. We investigated the relationships of total testosterone (TT) and serum Hcy levels with MetS in male Korean workers. Methods: We conducted a cross-sectional study including 8,606 male workers, aged 20 to 58 years, who underwent a physical examination in 2015. MetS was diagnosed based on the criteria of the 2009 harmonized definition, while the Korean standard for waist circumference (WC) was used. Participants’ biochemical parameters, including TT and serum Hcy, were measured, and participants were divided into quartiles. Multiple logistic regression models were used to estimate the association of MetS and its individualcomponents depending on TT and serum Hcy quartiles. Results: The prevalence of MetS in the study population was 16%. TT was lower in participants with MetS than in those withoutMetS (P<0.001). By contrast, Hcy level was similar between groups (P=0.694). In multiple logistic regression analysis, the oddsratio for the lowest TT quartile was 1.29 (95% confidence interval, 1.06 to 1.57) after adjusting for potential confounders. Participants with lower TT were more likely to have high WC, hypertriglyceridemia, and low high density lipoprotein levels. Serum Hcy levels were not significantly associated with MetS. Of the five components of MetS, only WC was significantly associated with serum Hcy. Conclusion: In male Korean workers, TT may be an independent predictor of MetS, and serum Hcy levels could be a marker of abdominal obesity. However, future prospective studies are needed.
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참고문헌 (50)
참고문헌 신청
Lim S / 2011 / Increasing prevalence of metabolic syndrome in Korea : the Korean National Health and Nutrition Examination Survey for 1998-2007 / Diabetes Care 34:1323~1328
Andreadis EA / 2007 / Metabolic syndrome and incident cardiovascular morbidity and mortality in a Mediterranean hypertensive population / Am J Hypertens 20:558~564
Brand JS / 2014 / Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies / PLoS One 9:e100409
Haring R / 2009 / Prediction of metabolic syndrome by low serum testosterone levels in men : results from the study of health in Pomerania / Diabetes 58:2027~2031
Li C / 2010 / Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men / Diabetes Care 33:1618~1624
Andreadis EA / 2007 / Metabolic syndrome and incident cardiovascular morbidity and mortality in a Mediterranean hypertensive population / Am J Hypertens 20:558~564
Brand JS / 2014 / Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies / PLoS One 9:e100409
Haring R / 2009 / Prediction of metabolic syndrome by low serum testosterone levels in men : results from the study of health in Pomerania / Diabetes 58:2027~2031
Li C / 2010 / Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men / Diabetes Care 33:1618~1624
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