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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 189 - 194 (6page)
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초록· 키워드
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Background: The role of uric acid in the development of diabetic peripheral neuropathy remains unclear. This study aimed to determine the association between uric acid and peripheral neuropathy among type 2 diabetes mellitus (T2DM) patients. Methods: We conducted a nationwide cross-sectional study based on the diabetes and hypertension study of the Medical Research Network of the Consortium of Thai Medical Schools. Adult T2DM patients from 831 public hospitals in Thailand were evaluated. The serum uric acid level was categorized into five groups based on quintiles (<4.4, 4.4–5.3, 5.3–6.2, 6.2–7.3, and >7.3 mg/dL). A multivariate logistic regression model was used to assess the independent association between serum uric acid level and peripheral neuropathy. Results: In total, 7,511 T2DM patients with available data about serum uric acid levels were included in the analysis. The mean age of the participants was 61.7±10.9 years, and approximately 35.6% were men. The prevalence rate of peripheral neuropathy was 3.0%. Moreover, the prevalence rates of peripheral neuropathy stratified according to uric acid levels <4.4, 4.4–5.3, 5.3–6.2, 6.2–7.3, and >7.3 mg/dL were 2.5%, 2.8%, 2.4%, 2.5%, and 4.7%, respectively. A serum uric acid level ≥7.3 mg/dL was found to be associated with an increase in odds ratio (1.54; 95% confidence interval, 1.02–2.32) for peripheral neuropathy compared with a serum uric acid level <4.4 mg/dL. Conclusion: Serum uric acid level is independently associated with peripheral neuropathy in T2DM patients, and elevated serum uric acid levels should be considered a risk factor for diabetic peripheral neuropathy in clinical practice.
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참고문헌 (30)
참고문헌 신청
Rowley WR / 2017 / Diabetes 2030 : insights from yesterday, today, and future trends / Popul Health Manag 20:6~12
Waldfogel JM / 2017 / Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life : a systematic review / Neurology 88:1958~1967
Pop-Busui R / 2017 / Diabetic neuropathy : a position statement by the American Diabetes Association / Diabetes Care 40:136~154
Barrett EJ / 2017 / Diabetic microvascular disease : an endocrine society scientific statement / J Clin Endocrinol Metab 102:4343~4410
Feldman EL / 2017 / New horizons in diabetic neuropathy : mechanisms, bioenergetics, and pain / Neuron 93:1296~1313
Waldfogel JM / 2017 / Pharmacotherapy for diabetic peripheral neuropathy pain and quality of life : a systematic review / Neurology 88:1958~1967
Pop-Busui R / 2017 / Diabetic neuropathy : a position statement by the American Diabetes Association / Diabetes Care 40:136~154
Barrett EJ / 2017 / Diabetic microvascular disease : an endocrine society scientific statement / J Clin Endocrinol Metab 102:4343~4410
Feldman EL / 2017 / New horizons in diabetic neuropathy : mechanisms, bioenergetics, and pain / Neuron 93:1296~1313
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