지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 241 - 251 (11page)
- DOI
- 10.3349/ymj.2022.63.3.241
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초록· 키워드
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Purpose: Here, we aimed to elucidate the differences in microbiota composition between patients with gout and those with asymptomatichyperuricemia (asHU) and determine the effect of uric acid-lowering therapy (ULT) on the gut microbiome.
Materials and Methods: Stool samples from patients with asHU (n=8) and three groups of gout patients, i.e., acute gout patientsbefore ULT (0ULT, n=14), the same acute gout patients after 30-day ULT (30ULT, n=9), and chronic gout patients after ≥6-monthULT (cULT, n=18) were collected and analyzed using 16S rRNA gene-based pyrosequencing. The composition of microbial taxonomyand communities, species diversity, and relationships among microbial communities were elucidated by bioinformaticanalysis.
Results: Gout patients showed less diverse gut microbiota than asHU patients. The microbiota of the asHU group exhibited a higherFirmicutes-to-Bacteroidetes (F/B) ratio and lower Prevotella-to-Bacteroides (P/B) ratio than the gout group; significantly, the F/Bratio increased in gout patients after ULT. Moreover, a balanced enterotype populated asHU patients compared to gout patients.
Notably, the gut microbiota in asHU patients had a higher proportion of taxa with potentially anti-inflammatory effects comparedto the gut microbiota in gout patients.
Conclusion: We found that microbial composition differs between asHU and gout patients. The differential gut microbiota inasHU patients may protect against gout development, whereas that in gout patients may have a role in gout provocation. ULT ingout patients altered the gut microbiota, and may help alleviate gout pathology and mitigate gout progression.
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