지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,147 - 1,163 (17page)
이용수
초록· 키워드
오류제보하기
Background As cattle represent one of the most important livestock species for meat production, control of muscle development in regards to quality is an important research focus. Objectives In this study, the phenotypic quality traits and its associations with DNA methylation levels of the longissimus muscle in two cattle breeds were studied. Methods The pH value, water loss rate, fat and protein and fatty acid content were measured in three beef cattle breeds of longissimus mucle; The longissimus mucle was analyzed by MethylRAD-seq and RNA-seq. The differentially methylated and differentially expressed related genes were subjected to BSP. Results Methylation status of longissimus mucle was analyzed by MethylRAD-seq. Compared with Simmental, there were 39 differentially methylated and expressed genes in muscle of Yunling cattle, and 123 differentially methylated and expressed genes in Wenshan muscle. A combined analysis of MethylRAD-seq and RNA-seq results revealed differential methylation and expression level of 18 genes between Simmental and Wenshan cattle, and 14 genes between Simmental and Yunling cattle. In addition, 28 genes were differentially methylated between Wenshan and Yunling cattle. Results of promoter methylation analysis of ACAD11, FADS6 and FASN showed that the overall degree of DNA methylation of FADS6 and FASN was negatively correlated with their expression levels. Methylation level of FASN in Simmental was greater than Yunling and Wenshan. The degree of methylation at the FADS6 CpG4 site was significantly higher in Simmental than that in Yunling. The levels of methylation at the CpG7 locus of the Simmental and Yunling breeds were greater than Wenshan cattle. A negative correlation was detected between the methylation levels and the expression of FASN CpG1, CpG2, CpG3, CpG5, CpG7, and CpG10. Conclusion The functional and molecular regulatory mechanism of the genes related to meat quality can be revealed systematically from aspects of the genetic and epigenetic regulation. These studies will help to further explore the molecular mechanisms and phenotypic differences that regulate growth and quality of different breeds of cattle.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Abdelrahman MM / 2017 / Chromatographic methods for quantitative determination of ampicillin, dicloxacillin and their impurity 6-aminopenicillanic acid / J Chromatogr Sci 56:209~215
Ahnstrom ML / 2012 / Effects of pelvic suspension of beef carcasses on quality and physical traits of five muscles from four gender-age groups / Meat Sci 90:528~535
Alberti P / 2017 / Effect of including whole linseed and vitamin E in the diet of young bulls slaughtered at two fat covers on the sensory quality of beef packaged in two different packaging systems / J Sci Food Agric 97:753~760
An YC / 2017 / Dynamic changes of genome-wide DNA methylation during soybean seed development / Sci Rep 7:12263
Arelovich HM / 2017 / Feeding value of whole raw soya beans as a protein supplement for beef cattle consuming low-quality forages / J Anim Physiol Anim Nutr 102:421~430
Ahnstrom ML / 2012 / Effects of pelvic suspension of beef carcasses on quality and physical traits of five muscles from four gender-age groups / Meat Sci 90:528~535
Alberti P / 2017 / Effect of including whole linseed and vitamin E in the diet of young bulls slaughtered at two fat covers on the sensory quality of beef packaged in two different packaging systems / J Sci Food Agric 97:753~760
An YC / 2017 / Dynamic changes of genome-wide DNA methylation during soybean seed development / Sci Rep 7:12263
Arelovich HM / 2017 / Feeding value of whole raw soya beans as a protein supplement for beef cattle consuming low-quality forages / J Anim Physiol Anim Nutr 102:421~430
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of aberrantly methylated androgen receptor target gene PCDH7 on the development of androgen-independent prostate cancer cells
Genes & Genomics
2020 .01
-
Smoking May Affect Pulmonary Function through DNA Methylation: an Epigenome-Wide Association Study in Korean Men
Clinical Nutrition Research
2020 .01
-
DNA Methylation Profiles of Blood Cells Are Distinct between Early-Onset Obese and Control Individuals
Genomics & informatics
2017 .01
-
In vivo evidence on the functional variation within fatty acid synthase gene associated with lipid metabolism in bovine longissimus dorsi muscle tissue
Genes & Genomics
2018 .01
-
Alteration of DNA Methylation in Gastric Cancer with Chemotherapy
Journal of Microbiology and Biotechnology
2017 .01
-
Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice
Nutrition Research and Practice
2017 .04
-
Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice
Nutrition Research and Practice
2017 .04
-
A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon
Nutrition Research and Practice
2015 .08
-
A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon
Nutrition Research and Practice
2015 .08
-
Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters
Genomics & informatics
2016 .01
-
Genome-Wide Analysis of DNA Methylation beforeand after Exercise in the Thoroughbred Horse with MeDIP-Seq
Molecules and Cells
2015 .03
-
Identification of DNA methylation and genetic alteration simultaneously from a single blood biopsy
Genes & Genomics
2023 .05
-
DNA methylation of GDF-9 and GHR genes as epigenetic regulator of milk production in Egyptian Zaraibi goat
Genes & Genomics
2024 .01
-
COEX-Seq: Convert a Variety of Measurements of Gene Expression in RNA-Seq
Genomics & informatics
2018 .01
-
Methylation Levels of LINE-1 As a Useful Marker for Venous Invasion in Both FFPE and Frozen Tumor Tissues of Gastric Cancer
Molecules and Cells
2017 .05
-
Genome-wide DNA methylation profiling in differentiating Crohn’s disease from intestinal tuberculosis
Genes & Genomics
2022 .05
-
Genome wide methylation analysis to uncover genes related to recurrent pregnancy loss
Genes & Genomics
2021 .01
-
Genome-wide DNA methylation profiles of maternal peripheral blood and placentas: potential risk factors for preeclampsia and validation of GRK5
Genes & Genomics
2017 .01
-
Methylome Analysis of Two Xanthomonas spp. Using Single-Molecule Real-Time Sequencing
The Plant Pathology Journal
2016 .12
-
Evolutionary Analyses of Hanwoo (Korean Cat-tle)-Specific Single-Nucleotide Polymorphisms and Genes Using Whole-Genome Resequencing Data of a Hanwoo Population
Molecules and Cells
2016 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0