메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Wu Hao (Zhongshan Hospital Fudan University People’s Republic of China) Liu Hongchun (Zhongshan Hospital Fudan University People’s Republic of China) Liu Haining (Zhongshan Hospital Fudan University People’s Republic of China) Chen Yanjie (Zhongshan Hospital Fudan University People’s Republic of China) Liu Taotao (Zhongshan Hospital Fudan University People’s Republic of China) Shen Xizhong (Zhongshan Hospital Fudan University People’s Republic of China) Liu Lili (Zhongshan Hospital Fudan University People’s Republic of China)
저널정보
한국유전학회 Genes & Genomics Genes & Genomics Vol.44 No.5
발행연도
2022.5
수록면
603 - 615 (13page)
DOI
10.1007/s13258-022-01224-1

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background Differential diagnosis of Crohn’s disease (CD) and intestinal tuberculosis (ITB) is still difficult in clinical pratice. DNA methylation has been considered as a favorable area for biomarker exploration and identification. Objective The purpose of the current study was to evaluate DNA methylation changes between CD and ITB. Methods We performed a genome-wide association study to identify differentially methylated positions (DMPs), including 8 CD patients (before the initial of biologics or immunomodulators), 6 ITB patients, and 8 healthy controls (HCs), in whole blood DNA using the Infinium HumanMethylation850 BeadChip. Results Patients in the CD group and ITB group were all observed with hypo-methylated changes compared with HCs. However, the CD group overlaps with the ITB group in DNA methylation, suggesting a stable epigenetic profile between the two diseases. The pathway enrichment analysis showed the alternation in inflammation-related pathway, immune system, and signal transduction. Focused on the DMPs located in the promoter region, further analysis indicated hypermethylation of cg03122532 (5′UTR of KCNJ15) could be a potential CD-specific biomarker. Conclusions We identified specific differential methylation loci related to CD and ITB in blood DNA. DNA metylation as a important epigenetic modification could contribute to the pathogenesis study and biomarker exploration of the diseases.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0