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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 134 - 144 (11page)
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Smoking is a risk factor for various disease outcomes and is one of the modifiers of DNA methylation. We aimed to identify smoking-related DNA methylation sites (CpG-sites) and test whether one identified CpG-site is associated with smoking-related traits and pulmonary function. We obtained DNA methylation data of 209 men from the Korean Genome and Epidemiology Study analyzed by Illumina's HumanMethylation450 array. To identify smoking-related DNA methylation sites, epigenome-wide association analysis of smoking status was conducted, adjusting for age, area, current drinking status, and body mass index. We assessed the association between smoking intensity and DNA methylation of cg05951221 (AHRR), the CpG showing the strongest largest difference in DNA methylation among the 5 hypomethylated CpGs in current smokers compared to never smokers. The association between DNA methylation and pulmonary function was examined longitudinally resulting in a positive association between DNA methylation and forced expiratory volume in 1 second/forced vital capacity, regardless of adjustment for smoking status. This suggests that DNA methylation associates with long-term pulmonary function. Our study contributes to explaining the relationship between smoking and pulmonary function via DNA methylation.
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참고문헌 (33)
참고문헌 신청
GBD 2015 Tobacco Collaborators / 2017 / Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015 / Lancet 389:1885~1906
이은하 / 2010 / 한국인의 흡연과 사망 위험에 관한 코호트 연구 / 예방의학회지 43(2):151~158
Zahra A / 2017 / Burden of disease attributable to smoking in Korea / Asia Pac J Public Health 29:47~59
Moore LD / 2013 / DNA methylation and its basic function / Neuropsychopharmacology 38:23~38
Lee KW / 2013 / Cigarette smoking and DNA methylation / Front Genet 4:132
이은하 / 2010 / 한국인의 흡연과 사망 위험에 관한 코호트 연구 / 예방의학회지 43(2):151~158
Zahra A / 2017 / Burden of disease attributable to smoking in Korea / Asia Pac J Public Health 29:47~59
Moore LD / 2013 / DNA methylation and its basic function / Neuropsychopharmacology 38:23~38
Lee KW / 2013 / Cigarette smoking and DNA methylation / Front Genet 4:132
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