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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 692 - 698 (7page)
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초록· 키워드
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Advances in next generation sequencing (NGS) technologies have enabled population-level studies for many animals to unravel the relationships between genotypic differences and traits of specific populations. The objective of this study was to perform evolutionary analysis of single nucleotide polymorphisms (SNP) in genes of Korean native cattle Hanwoo in comparison to SNP data from four other cattle breeds (Jersey, Simmental, Angus, and Holstein) and four related species (pig, horse, human, and mouse) obtained from public databases through NGS-based resequencing. We analyzed population structures and differentiation levels for the five cattle breeds and estimated species-specific SNPs with their origins and phylogenetic relationships among species. In addition, we identified Hanwoo-specific genes and proteins, and determined distinct changes in protein-protein interactions among five species (cattle, pig, horse, human, mouse) in the STRING network database by additionally considering indirect protein interactions. We found that the Hanwoo popula-tion was clearly different from the other four cattle populations. There were Hanwoo-specific genes related to its meat trait. Protein interaction rewiring analysis also confirmed that there were Hanwoo-specific protein-protein interactions that might have contributed to its unique meat quality.
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등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Ai, H. / 2015 / Adaptation and possible ancient interspecies introgression in pigs identified by wholegenome sequencing / Nat. Genet 47:217~225
Alexander, D. H. / 2009 / Fast modelbased estimation of ancestry in unrelated individuals / Genome Res 19:1655~1664
Begun, D. J. / 2007 / Population genomics : whole-genome analysis of polymorphism and divergence in Drosophila simulans / PLoS Biol 5:310
Bickhart, D. M. / 2012 / Copy number variation of individual cattle genomes using next-generation sequencing / Genome Res 22:778~790
Cho, M. / 2015 / evoSNPI:a pipeline for the evolutionary analysis of the origin of single nucleotide polymorphisms and the change of protein interactions / Proceedings of the 6th Computational Systems-Biology and Bioinformatics (CSBio2015) :17~21
Alexander, D. H. / 2009 / Fast modelbased estimation of ancestry in unrelated individuals / Genome Res 19:1655~1664
Begun, D. J. / 2007 / Population genomics : whole-genome analysis of polymorphism and divergence in Drosophila simulans / PLoS Biol 5:310
Bickhart, D. M. / 2012 / Copy number variation of individual cattle genomes using next-generation sequencing / Genome Res 22:778~790
Cho, M. / 2015 / evoSNPI:a pipeline for the evolutionary analysis of the origin of single nucleotide polymorphisms and the change of protein interactions / Proceedings of the 6th Computational Systems-Biology and Bioinformatics (CSBio2015) :17~21
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