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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제8호
- 발행연도
- 2017.1
- 수록면
- 1,367 - 1,378 (12page)
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초록· 키워드
오류제보하기
Epigenetic alterations such as DNA methylation, histone acetylation, and chromatin remodeling can control gene expression by regulating gene transcription. DNA methylation is one of the frequent epigenetic events that play important roles in cancer development. Cancer cells can gain significant resistance to anticancer drugs and escape programmed cell death through major epigenetic changes, including DNA methylation. To date, several research groups have identified instances of both (i) hypermethylation of tumor suppressor genes, and (ii) global hypomethylation of oncogenes. These changes in DNA methylation status could be used as biomarkers for the diagnosis and prognosis of cancer patients undergoing chemotherapies or other clinical therapies. Herein, we describe genes for which methylation is dependent upon anticancer drug resistance in patients with gastric cancer; we then suggest a significant epigenetic target to focus on for overcoming anticancer drug resistance.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Baylin SB. / 2005 / DNA methylation and gene silencing in cancer / Nat. Rev. Clin. Oncol 2 : S4 ~
Carcas LP. / 2014 / Gastric cancer review / J. Carcinog 13 : 14 ~
Chen C-C / 2015 / Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells / Cancer Cell Int 15 : 98 ~
Das PM / 2004 / DNA methylation and cancer / J. Clin. Oncol 22 : 4632 ~ 4642
Etoh T / 2004 / Increased DNA methyltransferase 1(DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of mu
Carcas LP. / 2014 / Gastric cancer review / J. Carcinog 13 : 14 ~
Chen C-C / 2015 / Changes in DNA methylation are associated with the development of drug resistance in cervical cancer cells / Cancer Cell Int 15 : 98 ~
Das PM / 2004 / DNA methylation and cancer / J. Clin. Oncol 22 : 4632 ~ 4642
Etoh T / 2004 / Increased DNA methyltransferase 1(DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of mu
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