지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 500 - 507 (8page)
이용수
초록· 키워드
오류제보하기
Single-molecule real-time (SMRT) sequencing allows identification of methylated DNA bases and methylation patterns/motifs at the genome level. Using SMRT sequencing, diverse bacterial methylomes including those of Helicobacter pylori, Lactobacillus spp., and Escherichia coli have been determined, and previously unreported DNA methylation motifs have been identified. However, the methylomes of Xanthomonas species, which belong to the most important plant pathogenic bacterial genus, have not been documented. Here, we report the methylomes of Xanthomonas axonopodis pv. glycines (Xag) strain 8ra and X. campestris pv. vesicatoria (Xcv) strain 85-10. We identified N<sup>6</sup>- methyladenine (6mA) and N<sup>4</sup>-methylcytosine (4mC) modification in both genomes. In addition, we assigned putative DNA methylation motifs including previously unreported methylation motifs via REBASE and MotifMaker, and compared methylation patterns in both species. Although Xag and Xcv belong to the same genus, their methylation patterns were dramatically different. The number of 4mC DNA bases in Xag (66,682) was significantly higher (29 fold) than in Xcv (2,321). In contrast, the number of 6mA DNA bases (4,147) in Xag was comparable to the number in Xcv (5,491). Strikingly, there were no common or shared motifs in the 10 most frequently methylated motifs of both strains, indicating they possess unique species- or strain-specific methylation motifs. Among the 20 most frequent motifs from both strains, for 9 motifs at least 1% of the methylated bases were located in putative promoter regions. Methylome analysis by SMRT sequencing technology is the first step toward understanding the biology and functions of DNA methylation in this genus.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effect of aberrantly methylated androgen receptor target gene PCDH7 on the development of androgen-independent prostate cancer cells
Genes & Genomics
2020 .01
-
OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor
Molecules and Cells
2018 .09
-
Smoking May Affect Pulmonary Function through DNA Methylation: an Epigenome-Wide Association Study in Korean Men
Clinical Nutrition Research
2020 .01
-
DNA Methylation Profiles of Blood Cells Are Distinct between Early-Onset Obese and Control Individuals
Genomics & informatics
2017 .01
-
A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon
Nutrition Research and Practice
2015 .08
-
A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon
Nutrition Research and Practice
2015 .08
-
Alteration of DNA Methylation in Gastric Cancer with Chemotherapy
Journal of Microbiology and Biotechnology
2017 .01
-
Classification of Colon Cancer Patients Based on the Methylation Patterns of Promoters
Genomics & informatics
2016 .01
-
Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice
Nutrition Research and Practice
2017 .04
-
Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice
Nutrition Research and Practice
2017 .04
-
Identification of DNA methylation and genetic alteration simultaneously from a single blood biopsy
Genes & Genomics
2023 .05
-
Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging
Nutrition Research and Practice
2023 .08
-
Modulation of DNA methylation by one-carbon metabolism: a milestone for healthy aging
Nutrition Research and Practice
2023 .08
-
Role of DNA Methylation in Antibiotics-driven Perturbation on the Gut Microbiome
한국미생물학회 학술대회논문집
2022 .10
-
DNA methylation and histone modifications induced by abiotic stressors in plants
Genes & Genomics
2022 .03
-
Genome-wide DNA methylation profiling in differentiating Crohn’s disease from intestinal tuberculosis
Genes & Genomics
2022 .05
-
An Optimized Method for the Construction of a DNA Methylome from Small Quantities of Tissue or Purified DNA from Arabidopsis Embryo
Molecules and Cells
2021 .08
-
BMP3 promoter hypermethylation in plasma-derived cell-free DNA in colorectal cancer patients
Genes & Genomics
2018 .01
-
Genome-wide locus-specific DNA methylation repatterning may facilitate rapid evolution of mercury resistance in rice
Genes & Genomics
2022 .03
-
Bacterial Epi-metagenomics : Measuring DNA Methylation Patterns in Bacterial Community Level
한국미생물학회 학술대회논문집
2016 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0102-2023-481-001833384