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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 289 - 294 (6page)
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In Korean cattle, intramuscular fat (IMF), or marbling, of the longissimus dorsi muscle (LM) cross section is one of the most important indicators of beef quality and are influenced by environmental and genetic factors. This study was to evaluate the effect of SNPs on the beef quality in Korean cattle for functional studies, such as site-directed mutagenesis based on bovine adipocytes. The fatty acid synthase (FASN) gene plays an important role in lipogenesis. FASN is an essential metabolic and multifunctional enzyme in fatty acid synthesis. Several studies have reported that SNPs g.841G, g.16024A, g.16039T, and g.17924G have a significant impact on marbling scores in Korean cattle and Japanese Black cattle population. These SNPs are located in transcription factor binding sites, the beta-ketoacyl reductase, and thioesterase domains. Our results revealed that the g.17924 A>G SNP is located in the thioesterase domain of the FASN protein, and changes from polar, neutral, and hydrophilic to nonpolar, aliphatic, and hydrophobic, respectively. In in vivo LM tissue of Korean cattle, the g.17924A>G SNP has an effect on increasing fat deposition. Therefore, g.17924A>G SNP could be a causal mutation for increasing fat deposition in Korean cattle LM tissue.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Abe T / 2009 / Novel mutations of the FASN gene and their effect on fatty acid composition in Japanese black beef / Biochem Genet 47:397~411
M.S.A. Bhuiyan / 2009 / DNA Polymorphisms in SREBF1 and FASN Genes Affect Fatty Acid Composition in Korean Cattle (Hanwoo) / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 22(6):765~773
Cheong HS / 2008 / A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle / BMC Genet 9:33
Goto T / 2006 / Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells / J Bone Miner Res 21:661~673
Hausman GJ / 2009 / Boardinvited review: the biology and regulation of preadipocytes and adipocytes in meat animals / J Anim Sci 87:1218~1246
M.S.A. Bhuiyan / 2009 / DNA Polymorphisms in SREBF1 and FASN Genes Affect Fatty Acid Composition in Korean Cattle (Hanwoo) / ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 22(6):765~773
Cheong HS / 2008 / A single nucleotide polymorphism in CAPN1 associated with marbling score in Korean cattle / BMC Genet 9:33
Goto T / 2006 / Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells / J Bone Miner Res 21:661~673
Hausman GJ / 2009 / Boardinvited review: the biology and regulation of preadipocytes and adipocytes in meat animals / J Anim Sci 87:1218~1246
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