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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 139 - 144 (6page)
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Somatic RUNX1 mutations are found in approximately 10% of patients with de novo acute myeloid leukemia (AML), but are more common in secondary forms of myelodysplastic syndrome (MDS) or AML. Particularly, this applies to MDS/AML developing from certain types of leukemia-prone inherited bone marrow failure syndromes. How these RUNX1 mutations contribute to the pathobiology of secondary MDS/AML is still unknown. This mini-review focusses on the role of RUNX1 mutations as the most common secondary leukemogenic hit in MDS/AML evolving from severe congenital neutropenia (SCN).
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참고문헌 (42)
참고문헌 신청
Antony-Debre, I. / 2015 / Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia / Blood 125:930~940
Beekman, R. / 2012 / Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia / Blood 119:5071~5077
Bellissimo, D. C. / 2017 / RUNX1 mutations in inherited and sporadic leukemia / Front. Cell Dev. Biol 5:111
Cai, X. / 2011 / Runx1 loss minimally impacts long-term hematopoietic stem cells / PLoS One 6:e28430
Chen, C. Y. / 2007 / RUNX1 gene mutation in primary myelodysplastic syndrome--the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome / Br. J. Haematol 139:405~414
Beekman, R. / 2012 / Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia / Blood 119:5071~5077
Bellissimo, D. C. / 2017 / RUNX1 mutations in inherited and sporadic leukemia / Front. Cell Dev. Biol 5:111
Cai, X. / 2011 / Runx1 loss minimally impacts long-term hematopoietic stem cells / PLoS One 6:e28430
Chen, C. Y. / 2007 / RUNX1 gene mutation in primary myelodysplastic syndrome--the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome / Br. J. Haematol 139:405~414
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