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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 176 - 181 (6page)
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초록· 키워드
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The RUNX transcription factors serve as master regulators of development and are frequently dysregulated in human cancers. Among the three family members, RUNX3 is the least studied, and has long been considered to be a tumor-suppressor gene in human cancers. This idea is mainly based on the observation that RUNX3 is inactivated by genetic/epigenetic alterations or protein mislocalization during the initiation of tumorigenesis. Recently, this paradigm has been challenged, as several lines of evidence have shown that RUNX3 is upregulated over the course of tumor development. Resolving this paradox and understanding how a single gene can exhibit both oncogenic and tumor-suppressive properties is essential for successful drug targeting of RUNX. We propose a simple explanation for the duality of RUNX3: p53 status. In this model, p53 deficiency causes RUNX3 to become an oncogene, resulting in aberrant upregulation of MYC.
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참고문헌 (75)
참고문헌 신청
Adorno, M. / 2009 / A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis / Cell 137:87~98
Bae, S. C. / 2019 / Functional relationship between p53 and RUNX proteins / J. Mol. Cell Biol 11:224~230
Barghout, S. H. / 2015 / RUNX3 contributes to carboplatin resistance in epithelial ovarian cancer cells / Gynecol. Oncol 138:647~655
Bauer, O. / 2015 / Loss of osteoblast Runx3 produces severe congenital osteopenia / Mol. Cell. Biol 35:1097~1109
Belver, L. / 2016 / The genetics and mechanisms of T cell acute lymphoblastic leukaemia / Nat. Rev. Cancer 16:494~507
Bae, S. C. / 2019 / Functional relationship between p53 and RUNX proteins / J. Mol. Cell Biol 11:224~230
Barghout, S. H. / 2015 / RUNX3 contributes to carboplatin resistance in epithelial ovarian cancer cells / Gynecol. Oncol 138:647~655
Bauer, O. / 2015 / Loss of osteoblast Runx3 produces severe congenital osteopenia / Mol. Cell. Biol 35:1097~1109
Belver, L. / 2016 / The genetics and mechanisms of T cell acute lymphoblastic leukaemia / Nat. Rev. Cancer 16:494~507
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CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
Molecules and Cells
2020 .01
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Role of RUNX Family Transcription Factors in DNA Damage Response
Molecules and Cells
2020 .01
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The Roles of RUNX Family Proteins in Development of Immune Cells
Molecules and Cells
2020 .01
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The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
Molecules and Cells
2020 .01
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Post-Translational Regulations of Transcriptional Activity of RUNX2
Molecules and Cells
2020 .01
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Molecular Mechanism of Runx2-Dependent Bone Development
Molecules and Cells
2020 .01
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RUNX1 Dosage in Development and Cancer
Molecules and Cells
2020 .01
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RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Molecules and Cells
2022 .12
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Molecules and Cells
2020 .01
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
2020 .01
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Involvement of RUNX and BRD Family Members in Restriction Point
Molecules and Cells
2019 .01
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K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
Molecules and Cells
2020 .01
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
Genes & Genomics
2024 .04
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
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RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
Molecules and Cells
2023 .04
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
2020 .01
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
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Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Molecules and Cells
2019 .01
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