지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 465 - 475 (11page)
- DOI
- 10.14348/molcells.2018.0051
이용수
초록· 키워드
오류제보하기
The advent of massively parallel sequencing, also called next-generation sequencing (NGS), has dramatically influenced cancer genomics by accelerating the identification of novel molecular alterations. Using a whole genome sequencing (WGS) approach, we identified somatic coding and noncoding variants that may contribute to leukemogenesis in 11 adult Korean acute myeloid leukemia (AML) patients, with serial tumor samples (primary and relapse) available for 5 of them; somatic variants were identified in 187 AML-related genes, including both novel (SIN3A, C10orf53, PTPRR, and RERGL) and well-known (NPM1, RUNX1, and CEPBA) AML-related genes. Notably, SIN3A expression shows prognostic value in AML. A newly designed method, referred to as “hot-zone” analysis, detected two putative functional noncoding variants that can alter transcription factor binding affinity near PPP1R10 and SRSF1. Moreover, the functional importance of the SRSF1 noncoding variant was further investigated by luciferase assays, which showed that the variant is critical for the regulation of gene expression leading to leukemogenesis. We expect that further functional investigation of these coding and noncoding variants will contribute to a more in-depth understanding of the underlying molecular mechanisms of AML and the development of targeted anti-cancer drugs.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Cancer Genome Atlas Research Network / 2013 / Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia / N. Engl. J. Med. 368:2059~2074
Cancer Genome Atlas Research Network / 2015 / Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas / N. Engl. J. Med. 372:2481~2498
Lianxiang Chen / 2016 / Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia / Molecules and Cells 39(4):330~336
Das, S. / 2014 / Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer / Mol. Cancer Res. 12:1195~1204
de Voer, R.M. / 2015 / Deleterious germline BLM mutations and the risk for early-onset colorectal cancer / Sci. Rep. 5:14060
Cancer Genome Atlas Research Network / 2015 / Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas / N. Engl. J. Med. 372:2481~2498
Lianxiang Chen / 2016 / Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia / Molecules and Cells 39(4):330~336
Das, S. / 2014 / Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer / Mol. Cancer Res. 12:1195~1204
de Voer, R.M. / 2015 / Deleterious germline BLM mutations and the risk for early-onset colorectal cancer / Sci. Rep. 5:14060
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Status of the SARS-CoV-2 Mutant Virus (Delta, Omicron) outbreak in Chungcheongnamdo, Korea in Early 2022
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .12
-
Effect of Next-Generation Exome Sequencing Depth for Discovery of Diagnostic Variants
Genomics & informatics
2015 .01
-
Rapid Genome Sequencing and Variant Typing of SARS-CoV-2 from Patient Samples
한국미생물학회 학술대회논문집
2021 .08
-
RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
2020 .01
-
Clinical and genetic analyses in syndromic intellectual disability with primary microcephaly reveal biallelic and de novo variants in patients with parental consanguinity
Genes & Genomics
2023 .01
-
SRSF7 is a promising prognostic biomarker in hepatocellular carcinoma and is associated with immune infiltration
Genes & Genomics
2024 .01
-
A Universal Analysis Pipeline for Hybrid Capture-Based Targeted Sequencing Data with Unique Molecular Indexes
Genomics & informatics
2018 .01
-
Description of novel variants in consanguineous Pakistani families affected with intellectual disability
Genes & Genomics
2023 .04
-
An efficient and tunable parameter to improve variant calling for whole genome and exome sequencing data
Genes & Genomics
2018 .01
-
PARK2 gene variants in Korean patients with Parkinson’s disease
Genes & Genomics
2016 .01
-
Catalytic Ability Improvement of Phenylalanine Hydroxylase from Chromobacterium violaceum by N-Terminal Truncation and Proline Introduction
Journal of Microbiology and Biotechnology
2019 .01
-
Frequency spectra characterization of noncoding human genomic sequences
Genes & Genomics
2020 .01
-
A fast and powerful aggregated Cauchy association test for joint analysis of multiple phenotypes
Genes & Genomics
2021 .01
-
Targeted next-generation sequencing for identifying genes related to horse temperament
Genes & Genomics
2017 .01
-
The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Molecules and Cells
2020 .01
-
Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia
Molecules and Cells
2016 .04
-
Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome
Genes & Genomics
2022 .05
-
Effects of p-coumaric acid on microRNA expression profiles in SNU-16 human gastric cancer cells
Genes & Genomics
2020 .01
-
A newly developed capture-based sequencing panel for genomic assay of lung cancer
Genes & Genomics
2020 .01
-
Selection probability of multivariate regularization to identify pleiotropic variants in genetic association studies
CSAM(Communications for Statistical Applications and Methods)
2020 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0