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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 836 - 839 (4page)
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초록· 키워드
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A tumor is an abnormal mass of tissue that arises when cells divide more than they should or do not die when they should. The cellular decision regarding whether to undergo division or death is made at the restriction (R)-point. Consistent with this, an increasingly large body of evidence indicates that deregulation of the R-point decision-making machinery accompanies the formation of most tumors. Although the R-point decision is literally a matter of life and death for the cell, and thus critical for the health of the organism, it remains unclear how a cell chooses its own fate. Recent work demonstrated that the R-point constitutes a novel oncogene surveillance mechanism operated by R-point–associated complexes of which RUNX3 and BRD2 are the core factors (Rpa-RX3 complexes). Here, we show that not only RUNX3 and BRD2, but also other members of the RUNX and BRD families (RUNX1, RUNX2, BRD3, and BRD4), are involved in R-point regulation.
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참고문헌 (18)
참고문헌 신청
Belkina, A. C. / 2012 / BET domain co-regulators in obesity, inflammation and cancer / Nat. Rev. Cancer 12:465~477
Cheung, K. L. / 2017 / Distinct roles of Brd2 and Brd4 in potentiating the transcriptional program for Th17 cell differentiation / Mol. Cell 65:1068.e5~1080.e5
Chi, X. Z. / 2017 / Runx3plays a critical role in restriction-point and defense against cellular transformation / Oncogene 36:6884~6894
Filippakopoulos, P. / 2012 / Histone recognition and large-scale structural analysis of the human bromodomain family / Cell 149:214~231
Huang, H. / 2007 / Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails / BMC Struct. Biol 7:57
Cheung, K. L. / 2017 / Distinct roles of Brd2 and Brd4 in potentiating the transcriptional program for Th17 cell differentiation / Mol. Cell 65:1068.e5~1080.e5
Chi, X. Z. / 2017 / Runx3plays a critical role in restriction-point and defense against cellular transformation / Oncogene 36:6884~6894
Filippakopoulos, P. / 2012 / Histone recognition and large-scale structural analysis of the human bromodomain family / Cell 149:214~231
Huang, H. / 2007 / Solution structure of the second bromodomain of Brd2 and its specific interaction with acetylated histone tails / BMC Struct. Biol 7:57
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
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Role of RUNX Family Transcription Factors in DNA Damage Response
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The Roles of RUNX Family Proteins in Development of Immune Cells
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The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
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Post-Translational Regulations of Transcriptional Activity of RUNX2
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Molecular Mechanism of Runx2-Dependent Bone Development
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RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
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RUNX1 Dosage in Development and Cancer
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
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2024 .04
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K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
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Role of RUNX Family Members in G1 Restriction-Point Regulation
Molecules and Cells
2020 .01
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Role of RUNX Family Members in G1 Restriction-Point Regulation
Molecules and Cells
2020 .01
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
2020 .01
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