지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 886 - 895 (10page)
- DOI
- 10.14348/molcells.2022.2031
이용수
초록· 키워드
오류제보하기
Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development ofnovel molecule-targeting therapeutic agents. In this study, we report the importance of the runt-related transcription factor 1 (RUNX1) and RUNX1–Baculoviral IAP (inhibitor of apoptosis) Repeat-Containing 5 (BIRC5/survivin) axis in the proliferation of MRT cells, as it can be used as an ideal target for anti-tumor strategies. The mechanism of this reaction can be explained by the interaction of RUNX1 with the RUNX1-binding DNA sequence located in the survivin promoter and its positive regulation. Specific knockdown of RUNX1 led to decreased expression of survivin, which subsequently suppressed the proliferation of MRT cells in vitro and in vivo. We also found that our novel RUNX inhibitor, Chb-M, which switches off RUNX1 using alkylating agent-conjugated pyrrole-imidazole polyamides designed to specifically bind to consensus RUNX-binding sequences (5′-TGTGGT-3′), inhibited survivin expression in vivo. Taken together, we identified a novel interaction between RUNX1 and survivin in MRT. Therefore the negative regulation of RUNX1 activity may be a novel strategy for MRT treatment
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
Molecules and Cells
2020 .01
-
Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
Molecules and Cells
2020 .01
-
The Roles of RUNX Family Proteins in Development of Immune Cells
Molecules and Cells
2020 .01
-
Role of RUNX Family Transcription Factors in DNA Damage Response
Molecules and Cells
2020 .01
-
Post-Translational Regulations of Transcriptional Activity of RUNX2
Molecules and Cells
2020 .01
-
Molecular Mechanism of Runx2-Dependent Bone Development
Molecules and Cells
2020 .01
-
The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
Molecules and Cells
2020 .01
-
RUNX1 Dosage in Development and Cancer
Molecules and Cells
2020 .01
-
The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Molecules and Cells
2020 .01
-
Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
-
Involvement of RUNX and BRD Family Members in Restriction Point
Molecules and Cells
2019 .01
-
Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
2020 .01
-
Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
Genes & Genomics
2024 .04
-
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
-
RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
-
K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
Molecules and Cells
2020 .01
-
Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Molecules and Cells
2019 .01
-
RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
2020 .01
-
RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
Molecules and Cells
2023 .04
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0