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논문 기본 정보

자료유형
학술저널
저자정보
Masamitsu Mikami (Kyoto University) Tatsuya Masuda (kyoto university) Takuya Kanatani (Kyoto University) Katsutsugu Umeda (Kyoto University) Hidefumi Hiramatsu (Kyoto University) Hirohito Kubota (Kyoto University) Tomoo Daifu (Kyoto University) Atsushi Iwai (Kyoto University) Etsuko Yamamoto Hattori (Kyoto University) Kana Furuichi (Kyoto University) Saho Takasaki (Kyoto University) Sunao Tanaka (Kyoto University) Yasuzumi Matsui (Kyoto University) Hidemasa Matsuo (Kyoto University) Masahiro Hirata (Kyoto University Hospital) Tatsuki R. Kataoka (Kyoto University Hospital) Tatsutoshi Nakahata (Kyoto University) Yasumichi Kuwahara (Kyoto Prefectural University of Medicine) Tomoko Iehara (Kyoto Prefectural University of Medicine) Hajime Hosoi (Kyoto Prefectural University of Medicine) Yoichi Imai (Kyoto University) Junko Takita (Kyoto University) Hiroshi Sugiyama (Kyoto University) Souichi Adachi (Kyoto University) Yasuhiko Kamikubo (Kyoto University)
저널정보
한국분자세포생물학회 Molecules and Cells Molecules and Cells 제45권 제12호
발행연도
2022.12
수록면
886 - 895 (10page)
DOI
10.14348/molcells.2022.2031

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Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development ofnovel molecule-targeting therapeutic agents. In this study, we report the importance of the runt-related transcription factor 1 (RUNX1) and RUNX1–Baculoviral IAP (inhibitor of apoptosis) Repeat-Containing 5 (BIRC5/survivin) axis in the proliferation of MRT cells, as it can be used as an ideal target for anti-tumor strategies. The mechanism of this reaction can be explained by the interaction of RUNX1 with the RUNX1-binding DNA sequence located in the survivin promoter and its positive regulation. Specific knockdown of RUNX1 led to decreased expression of survivin, which subsequently suppressed the proliferation of MRT cells in vitro and in vivo. We also found that our novel RUNX inhibitor, Chb-M, which switches off RUNX1 using alkylating agent-conjugated pyrrole-imidazole polyamides designed to specifically bind to consensus RUNX-binding sequences (5′-TGTGGT-3′), inhibited survivin expression in vivo. Taken together, we identified a novel interaction between RUNX1 and survivin in MRT. Therefore the negative regulation of RUNX1 activity may be a novel strategy for MRT treatment

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