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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 160 - 167 (8page)
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Runt-related transcription factor 2 (RUNX2) is a key transcription factor for bone formation and osteoblast differentiation. Various signaling pathways and mechanisms that regulate the expression and transcriptional activity of RUNX2 have been thoroughly investigated since the involvement of RUNX2 was first reported in bone formation. As the regulation of Runx2 expression by extracellular signals has recently been reviewed, this review focuses on the regulation of post-translational RUNX2 activity. Transcriptional activity of RUNX2 is regulated at the post-translational level by various enzymes including kinases, acetyl transferases, deacetylases, ubiquitin E3 ligases, and prolyl isomerases. We describe a sequential and linear causality between post-translational modifications of RUNX2 by these enzymes. RUNX2 is one of the most important osteogenic transcription factors; however, it is not a suitable drug target. Here, we suggest enzymes that directly regulate the stability and/or transcriptional activity of RUNX2 at a post-translational level as effective drug targets for treating bone diseases.
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참고문헌 (62)
참고문헌 신청
Aronson, B. D. / 1997 / Groucho-dependent and-independent repression activities of Runt domain proteins / Mol. Cell. Biol 17:5581~5587
Bae, H. S. / 2017 / An HDAC inhibitor, entinostat/MS-275, partially prevents delayed cranial suture closure in heterozygous Runx2 null mice / J. Bone Miner. Res 32:951~961
Bae, S. C. / 1994 / PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials / Mol. Cell. Biol 14:3242~3252
Choi, J. Y. / 2001 / Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development / Proc. Natl. Acad. Sci. U. S. A 98:8650~8655
최강영 / 2002 / Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis / Experimental and Molecular Medicine 34(6):426~433
Bae, H. S. / 2017 / An HDAC inhibitor, entinostat/MS-275, partially prevents delayed cranial suture closure in heterozygous Runx2 null mice / J. Bone Miner. Res 32:951~961
Bae, S. C. / 1994 / PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials / Mol. Cell. Biol 14:3242~3252
Choi, J. Y. / 2001 / Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development / Proc. Natl. Acad. Sci. U. S. A 98:8650~8655
최강영 / 2002 / Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis / Experimental and Molecular Medicine 34(6):426~433
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RUNX1 Dosage in Development and Cancer
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
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Involvement of RUNX and BRD Family Members in Restriction Point
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
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Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
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RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
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Aqueous extract of Petasites japonicus leaves promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells
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Aqueous extract of Petasites japonicus leaves promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells
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