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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 126 - 138 (13page)
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The transcription factor RUNX1 first came to prominence due to its involvement in the t(8;21) translocation in acute myeloid leukemia (AML). Since this discovery, RUNX1 has been shown to play important roles not only in leukemia but also in the ontogeny of the normal hematopoietic system. Although it is currently still challenging to fully assess the different parameters regulating RUNX1 dosage, it has become clear that the dose of RUNX1 can greatly affect both leukemia and normal hematopoietic development. It is also becoming evident that varying levels of RUNX1 expression can be used as markers of tumor progression not only in the hematopoietic system, but also in non-hematopoietic cancers. Here, we provide an overview of the current knowledge of the effects of RUNX1 dosage in normal development of both hematopoietic and epithelial tissues and their associated cancers.
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참고문헌 (154)
참고문헌 신청
Aikawa, Y. / 2006 / Roles of HIPK1 and HIPK2 in AML1-and p300-dependent transcription, hematopoiesis and blood vessel formation / EMBO J 25:3955~3965
Angelos, M. G. / 2018 / Single cell resolution of human hematoendothelial cells defines transcriptional signatures of hemogenic endothelium / Stem Cells 36:206~217
Aronson, B. D. / 1997 / Groucho-dependent and-independent repression activities of Runt domain proteins / Mol. Cell. Biol 17:5581~5587
Bae, S. C. / 1993 / Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1 / Oncogene 8:809~814
Banach-Petrosky, W. / 2007 / Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice / Cancer Res 67:9089~9096
Angelos, M. G. / 2018 / Single cell resolution of human hematoendothelial cells defines transcriptional signatures of hemogenic endothelium / Stem Cells 36:206~217
Aronson, B. D. / 1997 / Groucho-dependent and-independent repression activities of Runt domain proteins / Mol. Cell. Biol 17:5581~5587
Bae, S. C. / 1993 / Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1 / Oncogene 8:809~814
Banach-Petrosky, W. / 2007 / Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice / Cancer Res 67:9089~9096
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CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
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Role of RUNX Family Transcription Factors in DNA Damage Response
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
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The Roles of RUNX Family Proteins in Development of Immune Cells
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Post-Translational Regulations of Transcriptional Activity of RUNX2
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
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Molecular Mechanism of Runx2-Dependent Bone Development
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The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
Molecules and Cells
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RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Molecules and Cells
2022 .12
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
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Involvement of RUNX and BRD Family Members in Restriction Point
Molecules and Cells
2019 .01
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
2020 .01
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
Genes & Genomics
2024 .04
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
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RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
Molecules and Cells
2023 .04
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
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K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
Molecules and Cells
2020 .01
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Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Molecules and Cells
2019 .01
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