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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 330 - 336 (7page)
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초록· 키워드
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Long non-coding RNAs (lncRNAs) are involved in multi-ple cellular events, as well as in tumorigenesis. Colon cancer-associated transcript-1 (CCAT1) gene encodes an lncRNA whose over-activation was observed in an expanding list of primary human solid tumors and tumor cell lines, however its biological roles in acute myeloid leukaemia (AML) has not been reported yet at present. In this study, the aberrant upregulation of CCAT1 was detected in French-American-British M4 and M5 subtypes of adult AML patients. By gain- and loss-of-function analysis, we determined that CCAT1 repressed monocytic differentiation and promoted cell growth of HL-60 by sequestering tumor suppressive miR-155. Accordingly, a significant decrease in miR-155 level was detected in AML patients. Re-introduction of miR-155 into HL-60 cells restored monocytic maturation and repressed cell proliferation. Furthermore, CCAT1 could up-regulated c-Myc via its competing endogenous RNA (ceRNA) activity on miR-155. In conclusion, these results revealed new mechanism of lncRNA CCAT1 in AML development, and suggested that the manipulation of CCAT1 expression could serve as a potential strategy in AML therapy.
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참고문헌 (38)
참고문헌 신청
Alaiyan, B. / 2013 / Differential expression of colon cancer associated transcript1(CCAT1)along the colonic adenoma-carcinoma sequence / BMC Cancer 13:196
Arancio, W. / 2014 / Competing endogenous RNA and interactome bioinformatic analyses on human telomerase / Rejuvenation Res 17:161~167
Calin, G. A. / 2005 / A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia / N Engl J. Med 353:1793~1801
Deng, L. / 2015 / Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge / J. Exper. Clin. Cancer Res 34:18
Eis, P. S. / 2005 / Accumulation of miR-155 and BIC RNA in human B cell lymphomas / Proc. Natl. Acad. Sci. USA 102:3627~3632
Arancio, W. / 2014 / Competing endogenous RNA and interactome bioinformatic analyses on human telomerase / Rejuvenation Res 17:161~167
Calin, G. A. / 2005 / A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia / N Engl J. Med 353:1793~1801
Deng, L. / 2015 / Long noncoding RNA CCAT1 promotes hepatocellular carcinoma progression by functioning as let-7 sponge / J. Exper. Clin. Cancer Res 34:18
Eis, P. S. / 2005 / Accumulation of miR-155 and BIC RNA in human B cell lymphomas / Proc. Natl. Acad. Sci. USA 102:3627~3632
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