지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 99 - 106 (8page)
이용수
초록· 키워드
오류제보하기
Cells are constantly exposed to endogenous and exogenous stresses that can result in DNA damage. In response, they have evolved complex pathways to maintain genomic integrity. RUNX family transcription factors (RUNX1, RUNX2, and RUNX3 in mammals) are master regulators of development and differentiation, and are frequently dysregulated in cancer. A growing body of research also implicates RUNX proteins as regulators of the DNA damage response, often acting in conjunction with the p53 and Fanconi anemia pathways. In this review, we discuss the functional role and mechanisms involved in RUNX factor mediated response to DNA damage and other cellular stresses. We highlight the impact of these new findings on our understanding of cancer predisposition associated with RUNX factor dysregulation and their implications for designing novel approaches to prevent cancer formation in affected individuals.
목차
등록된 정보가 없습니다.
참고문헌 (91)
참고문헌 신청
Akech, J. / 2010 / Runx2association with progression of prostate cancer in patients : mechanisms mediating bone osteolysis and osteoblastic metastatic lesions / Oncogene 29:811~821
Alcalay, M. / 2003 / Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair / J. Clin. Invest 112:1751~1761
Antony-Debré, I. / 2015 / Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia / Blood 125:930~940
Bae, S. C. / 2004 / Tumor suppressor activity of RUNX3 / Oncogene 23:4336~4340
Bellissimo, D. C. / 2017 / RUNX1 mutations in inherited and sporadic leukemia / Front. Cell Dev. Biol 5:111
Alcalay, M. / 2003 / Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair / J. Clin. Invest 112:1751~1761
Antony-Debré, I. / 2015 / Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia / Blood 125:930~940
Bae, S. C. / 2004 / Tumor suppressor activity of RUNX3 / Oncogene 23:4336~4340
Bellissimo, D. C. / 2017 / RUNX1 mutations in inherited and sporadic leukemia / Front. Cell Dev. Biol 5:111
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
Molecules and Cells
2020 .01
-
The Roles of RUNX Family Proteins in Development of Immune Cells
Molecules and Cells
2020 .01
-
Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
Molecules and Cells
2020 .01
-
Post-Translational Regulations of Transcriptional Activity of RUNX2
Molecules and Cells
2020 .01
-
Molecular Mechanism of Runx2-Dependent Bone Development
Molecules and Cells
2020 .01
-
RUNX1 Dosage in Development and Cancer
Molecules and Cells
2020 .01
-
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Molecules and Cells
2022 .12
-
The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
Molecules and Cells
2020 .01
-
Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
Genes & Genomics
2022 .06
-
The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Molecules and Cells
2020 .01
-
Involvement of RUNX and BRD Family Members in Restriction Point
Molecules and Cells
2019 .01
-
Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
2020 .01
-
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
-
Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
Genes & Genomics
2024 .04
-
RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Molecules and Cells
2023 .04
-
K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
Molecules and Cells
2020 .01
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
-
RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
2020 .01
-
RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
Molecules and Cells
2023 .04
-
Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
Molecules and Cells
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0