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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 107 - 113 (7page)
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The Runt-related transcription factors (RUNX) transcription factors have been known for their critical roles in numerous developmental processes and diseases such as autoimmune disorders and cancer. Especially, RUNX proteins are best known for their roles in hematopoiesis, particularly during the development of T cells. As scientists discover more types of new immune cells, the functional diversity of RUNX proteins also has been increased over time. Furthermore, recent research has revealed complicated transcriptional networks involving RUNX proteins by the current technical advances. Databases established by next generation sequencing data analysis has identified ever increasing numbers of potential targets for RUNX proteins and other transcription factors. Here, we summarize diverse functions of RUNX proteins mainly on lymphoid lineage cells by incorporating recent discoveries.
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참고문헌 (68)
참고문헌 신청
Bruno, L. / 2009 / Runx proteins regulate Foxp3 expression / J. Exp. Med 206:2329~2337
Cooper, M. A. / 2009 / Cytokine-induced memory-like natural killer cells / Proc. Natl. Acad. Sci. U. S. A 106:1915~1919
Cruz-Guilloty, F. / 2009 / Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs / J. Exp. Med 206:51~59
Djuretic, I. M. / 2007 / Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells / Nat. Immunol 8:145~153
Egawa, T. / 2005 / Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors / Immunity 22:705~716
Cooper, M. A. / 2009 / Cytokine-induced memory-like natural killer cells / Proc. Natl. Acad. Sci. U. S. A 106:1915~1919
Cruz-Guilloty, F. / 2009 / Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs / J. Exp. Med 206:51~59
Djuretic, I. M. / 2007 / Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells / Nat. Immunol 8:145~153
Egawa, T. / 2005 / Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors / Immunity 22:705~716
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CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
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Role of RUNX Family Transcription Factors in DNA Damage Response
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Post-Translational Regulations of Transcriptional Activity of RUNX2
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
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Molecular Mechanism of Runx2-Dependent Bone Development
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RUNX1 Dosage in Development and Cancer
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RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
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The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
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Identification a novel de novo RUNX2 frameshift mutation associated with cleidocranial dysplasia
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
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Involvement of RUNX and BRD Family Members in Restriction Point
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
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Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis
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The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
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RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
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2023 .04
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K-Ras?Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated
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Hypoxia Mediates Runt-Related Transcription Factor 2 Expression via Induction of Vascular Endothelial Growth Factor in Periodontal Ligament Stem Cells
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RUNX1 Mutations in the Leukemic Progression of Severe Congenital Neutropenia
Molecules and Cells
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RUNX1 Ameliorates Rheumatoid Arthritis Progression through Epigenetic Inhibition of LRRC15
Molecules and Cells
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