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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 46 - 53 (8page)
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Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.
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참고문헌 (48)
참고문헌 신청
Baumgart M / 2015 / Summary of the evidence on modifiable risk factors for cognitive decline and dementia : a population-based perspective / Alzheimers Dement 11:718~726
Huang CC / 2014 / Diabetes mellitus and the risk of Alzheimer’s disease : a nationwide population-based study / PLoS One 9:e87095
de la Torre JC / 2012 / Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia / Cardiovasc Psychiatry Neurol 2012:367516
Norton S / 2014 / Potential for primary prevention of Alzheimer’s disease : an analysis of populationbased data / Lancet Neurol 13:788~794
Ballard C / 2011 / Alzheimer’s disease / Lancet 377:1019~1031
Huang CC / 2014 / Diabetes mellitus and the risk of Alzheimer’s disease : a nationwide population-based study / PLoS One 9:e87095
de la Torre JC / 2012 / Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia / Cardiovasc Psychiatry Neurol 2012:367516
Norton S / 2014 / Potential for primary prevention of Alzheimer’s disease : an analysis of populationbased data / Lancet Neurol 13:788~794
Ballard C / 2011 / Alzheimer’s disease / Lancet 377:1019~1031
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