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Survival Analysis of Patients with Alzheimer's Disease: A Study Based on Data from the Korean National Health Insurance Services' Senior Cohort Database
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논문 기본 정보

Type
Academic journal
Author
Tae Ho Huh (Hallym University Dongtan Sacred Heart Hospital) Yoou jong (한림대학교) Jungjin Cho (한림대학교) KimMee-Young (한림대학교) YOUNG SU J (한림대학교)
Journal
대한가정의학회 Korean Journal of Family Medicine Korean Journal of Family Medicine 제41권 제4호 KCI Accredited Journals
Published
2020.1
Pages
214 - 221 (8page)

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Survival Analysis of Patients with Alzheimer's Disease: A Study Based on Data from the Korean National Health Insurance Services' Senior Cohort Database
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Background: Korea’s rapidly aging population has experienced a sharp rise in the prevalence of dementia. Patients with Alzheimer’s disease (AD), which is estimated to be about three-quarters of all patients with dementia, tend to have higher mortality rates compared with patients without Alzheimer’s disease. In this study, a survival analysis of patients with AD was conducted in order to provide knowledge to those who provide medical care to these patients. Methods: Data on individuals over 65 years old in 2004 were extracted from the Korean National Health Insurance Services’ Senior Cohort database (2002?2013). The subjects were 209,254 patients, including 2,695 who were first diagnosed with AD (the AD group) and 206,559 that had not been diagnosed with the disease (non-AD group). To investigate the independent effect of AD on survival, the Cox proportional-hazards model, hazard ratios (confidence interval of 95%), and the Kaplan-Meier method were used. Results: Mean survival time in the AD group was 5.3±3.3 years, which was about 2.5 years shorter than that in the non-AD group (7.8±2.4 years). The mortality rate in the AD group (66.3%) was higher than that in the non-AD group (26.3%). The adjusted hazard ratio in the AD group was 2.5 and, therefore, it was found that the AD group had a 2.5-fold higher risk of death than the non-AD group. Conclusion: Overall, AD has a large, independent impact on survival. Survival time was shorter, and the mortality rate and risk were generally higher in the AD group, compared with the non-AD group.
#Alzheimer Disease #Database #Survival Analysis #Mortality

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References (27)

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World Health Organization / 2018 / Towards a dementia plan : a WHO guide / World Health Organization google schola Kisler K / 2017 / Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease / Nat Rev Neurosci 18:419~434 google schola Folch J / 2018 / Review of the advances in treatment for Alzheimer disease : strategies for combating β-amyloid protein / Neurologia 33:47~58 google schola Tramutola A / 2017 / Oxidative stress, protein modification and Alzheimer disease / Brain Res Bull 133:88~96 google schola Kim SH / 2012 / Prevalence of dementia among the South Korean population / J Korean Diabetes 13:124~128 google schola

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