지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 79 - 84 (6page)
이용수
초록· 키워드
오류제보하기
Background: Pulsatility of cerebral arteries and aortic stiffness have been associated with white matter hyperintensities (WMH). We explored which is better correlated with the severity of WMH in a population with acute lacunar infarct. Methods: We included patients with acute small subcortical infarcts who underwent transcranial Doppler (TCD) and brachial ankle pulse wave velocity (baPWV). Exclusion criteria were any stenosis or occlusion on major cerebral arteries on magnetic resonance angiography; poor temporal insonation windows; ankle brachial index < 0.9; and atrial fibrillation. We assessed the performance of the pulsatility index of bilateral middle cerebral arteries (PI-MCA) and baPWV for predicting moderate- to-severe WMH, defined as an Age Related White Matter Changes score > 5, and then sought to find independent predictors using binary logistic regression analysis. Results: Eighty-three patients (56 males, mean age 61.5 ± 11.4) participated in the study. Univariate analysis showed old age and high PI-MCA were significantly correlated with moderate- to-severe WMH. However, baPWV was not associated with the severity of WMH. Multivariate analysis revealed old age (odds ratio per 1-year increase, 1.068; p = 0.044) and upper tertile of PI-MCA (odds ratio, 5.138; p = 0.049) were independently associated with moderate-to-severe WMH. Receiver-operating characteristics showed PI-MCA differentiated those with and without moderate-to-severe WMH with an area under the curve of 0.719. Conclusions: PI-MCA derived from TCD was better correlated with the severity of WMH than baPWV in a population with lacunar infarction. Pulsatility of cerebral arteries may better predict cerebral small vessel disease than the aortic stiffness index.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
O'Rourke MF / 2002 / Clinical applications of arterial stiffness; definitions and reference values / Am J Hypertens 15:426~444
Blacher J / 1999 / Impact of aortic stiffness on survival in end-stage renal disease / Circulation 99:2434~2439
Laurent S / 2001 / Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients / Hypertension 37:1236~1241
Sugawara J / 2005 / Brachial-ankle pulse wave velocity: an index of central arterial stiffness? / J Hum Hypertens 19:401~406
Legarth J / 1989 / Characteristics of doppler blood-velocity waveforms in a cardiovascular in vitro model. i. the model and the influence of pulse rate / Scand J Clin Lab Invest 49:451~457
Blacher J / 1999 / Impact of aortic stiffness on survival in end-stage renal disease / Circulation 99:2434~2439
Laurent S / 2001 / Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients / Hypertension 37:1236~1241
Sugawara J / 2005 / Brachial-ankle pulse wave velocity: an index of central arterial stiffness? / J Hum Hypertens 19:401~406
Legarth J / 1989 / Characteristics of doppler blood-velocity waveforms in a cardiovascular in vitro model. i. the model and the influence of pulse rate / Scand J Clin Lab Invest 49:451~457
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