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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.5
- 수록면
- 193 - 198 (6page)
- DOI
- 10.4082/kjfm.21.0129
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초록· 키워드
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Background: White matter hyperintensity (WMH) is a risk factor for dementia and ischemic stroke. The atherogen-ic index of plasma (AIP) is a simple and cost-effective marker for the prediction of various vascular diseases. In this study, we evaluated the relationship between AIP and WMH in adults without cerebrovascular accidents.Methods: We analyzed the data of 281 adults, aged ≥26 years, who underwent brain magnetic resonance imaging (MRI) at the health promotion center of an education hospital between January 2014 and December 2018. Partici-pants were divided into three categories according to tertiles of the AIP scores (T1: <0.20; T2: 0.20?0.48; and T3: >0.48). WMH was defined as a modified Fazekas scale score of 1?3 on brain MRI. A cubic spline curve was used to determine the linearity of the relationship between AIP and WMH. Multiple logistic regression analysis was used to evaluate the relationship between the AIP and WMH.Results: The prevalence of WMH was 45.7% in T1, 57.0% in T2, and 66.0% in T3 (T3 vs. T1, P for post-hoc analy-sis=0.005). The increased odds of WMH were associated with increased AIP. The odds ratio (OR) with a 95% confi-dence interval (CI) for WMH of T2 and T3 compared with T1 were 1.57 (0.88?2.80) and 2.30 (1.28?4.14), respective-ly. After adjusting for confounding variables, the OR with a 95% CI for WMH in the T2 and T3 groups vs. the referent T1 were 1.55 (0.76?3.13) and 2.27 (1.06?4.84), respectively.Conclusion: AIP is independently and positively associated with WMH in a healthy population.
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