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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제17권 제3호
- 발행연도
- 2018.1
- 수록면
- 120 - 129 (10page)
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Background and Purpose: Prospective memory (PM) has a known relationship with frontal function, and PM decline has been observed in amnestic mild cognitive impairment (aMCI). Cerebral small vessel disease, as evidenced by white matter hyperintensities (WMHs), is linked to frontal dysfunction. This study was undertaken to evaluate the relationship between PM decline and WMHs in patients with aMCI. Methods: Of 74 enrollees with aMCI, 69 completed this prospective study. We compared total scores and sub-scores of the Prospective and Retrospective Memory Questionnaire (PRMQ) administered at baseline and 3 months later, stratifying patients by degree of WMHs. Results: A significant decline was seen in PRMQ total scores and PM scores at the 3-month mark in patients with moderate (vs. mild) degrees of WMHs (−2.8±7.2 vs. 0.2±7.1; p =0.032). In addition, patients with moderate (vs. mild) degrees of deep WMHs (DWMHs) showed greater PM decline, whereas PM loss in patients with mild, moderate, or severe degrees of periventricular WMHs (PVWMHs) did not differ significantly. Conclusions: Findings of this study indicate that the burden of WMHs is consistently implicated in PM deterioration experienced by patients with aMCI, and signifies greater PM decline, especially in instances of extensive DWMHs. Greater attention to the change of PM is therefore needed in aMCI patients with WMHs.
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참고문헌 (60)
참고문헌 신청
Schacter DL / 2007 / The cognitive neuroscience of constructive memory: remembering the past and imagining the future / Philos Trans R Soc Lond B Biol Sci 362:773~786
Crystal JD / 2015 / Prospective memory: a comparative perspective / Behav Processes 112:88~99
Kliegel M / 2016 / Prospective memory in older adults: where we are now and what is next / Gerontology 62:459~466
Dermody N / 2016 / Prospective memory impairments in Alzheimer's disease and behavioral variant frontotemporal dementia: clinical and neural correlates / J Alzheimers Dis 50:425~441
Costa A / 2015 / Sensitivity of a time-based prospective memory procedure in the assessment of amnestic mild cognitive impairment / J Alzheimers Dis 44:63~67
Crystal JD / 2015 / Prospective memory: a comparative perspective / Behav Processes 112:88~99
Kliegel M / 2016 / Prospective memory in older adults: where we are now and what is next / Gerontology 62:459~466
Dermody N / 2016 / Prospective memory impairments in Alzheimer's disease and behavioral variant frontotemporal dementia: clinical and neural correlates / J Alzheimers Dis 50:425~441
Costa A / 2015 / Sensitivity of a time-based prospective memory procedure in the assessment of amnestic mild cognitive impairment / J Alzheimers Dis 44:63~67
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