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논문 기본 정보

자료유형
학술저널
저자정보
Cho Jaelim (Department of Preventive Medicine Yonsei University College of Medicine Seoul Korea.Institute for Environmental Research Yonsei University College of Medicine Seoul Korea.Institute of Human Complexity) Jang Heeseon (Department of Preventive Medicine Yonsei University College of Medicine Seoul Korea.) Noh Young (Department of Neurology Gachon University Gil Medical Center Incheon Korea.) Lee Seung-Koo (Department of Radiology Severance Hospital Yonsei University College of Medicine Seoul Korea.) Koh Sang-Baek (Department of Occupational and Environmental Medicine Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Korea.) Kim Sun-Young (Department of Cancer Control and Population Health Graduate School of Cancer Science and Policy National Cancer Center Goyang Korea.) Kim Changsoo (Department of Preventive Medicine Yonsei University College of Medicine Seoul Korea.Institute for Environmental Research Yonsei University College of Medicine Seoul Korea.Institute of Human Complexity)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.16
발행연도
2023.4
수록면
1 - 11 (11page)
DOI
10.3346/jkms.2023.38.e159

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Background: Numerous studies have shown the effect of particulate matter exposure on brain imaging markers. However, little evidence exists about whether the effect differs by the level of low-grade chronic systemic inflammation. We investigated whether the level of c-reactive protein (CRP, a marker of systemic inflammation) modifies the associations of particulate matter exposures with brain cortical gray matter thickness and white matter hyperintensities (WMH). Methods: We conducted a cross-sectional study of baseline data from a prospective cohort study including adults with no dementia or stroke. Long-term concentrations of particulate matter ≤ 10 µm in diameter (PM10) and ≤ 2.5 µm (PM2.5) at each participant’s home address were estimated. Global cortical thickness (n = 874) and WMH volumes (n = 397) were estimated from brain magnetic resonance images. We built linear and logistic regression models for cortical thickness and WMH volumes (higher versus lower than median), respectively. Significance of difference in the association between the CRP group (higher versus lower than median) was expressed as P for interaction. Results: Particulate matter exposures were significantly associated with a reduced global cortical thickness only in the higher CRP group among men (P for interaction = 0.015 for PM10 and 0.006 for PM2.5). A 10 μg/m3 increase in PM10 was associated with the higher volumes of total WMH (odds ratio, 1.78; 95% confidence interval, 1.07–2.97) and periventricular WMH (2.00; 1.20–3.33). A 1 μg/m3 increase in PM2.5 was associated with the higher volume of periventricular WMH (odds ratio, 1.66; 95% confidence interval, 1.08–2.56). These associations did not significantly differ by the level of high sensitivity CRP. Conclusion: Particulate matter exposures were associated with a reduced global cortical thickness in men with a high level of chronic inflammation. Men with a high level of chronic inflammation may be susceptible to cortical atrophy attributable to particulate matter exposures.
#Neuroimaging #Chronic Inflammation #Brain Cortical Thickness #White Matter Hyperintensity #Air Pollution

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