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논문 기본 정보

자료유형
학술저널
저자정보
Jung Young Hee (Department of Neurology Myoungji Hospital College of Medicine Hanyang University Goyang Korea.) Park Seongbeom (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Lee Na Kyung (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Stem Cell) Han Hyun Jeong (Department of Neurology Myoungji Hospital College of Medicine Hanyang University Goyang Korea.) Jang Hyemin (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Alzheimer’s Disease Convergence Research Center Samsung Medical Center Seoul Korea.) Kim Hee Jin (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Stem Cell) Seo Sang Won (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Alzheimer’s Disease Convergence Research Center Samsung Medical Center Seoul Korea.Department of D) Na Duk Lyul (Department of Neurology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Stem Cell)
저널정보
대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제22권 제1호
발행연도
2023.1
수록면
28 - 42 (15page)
DOI
10.12779/dnd.2023.22.1.28

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Background and Purpose: We investigated the correlation between the deep distribution of white matter hyperintensity (WMH) (dWMH: WMH in deep and corticomedullary areas, with minimal periventricular WMH) and a positive agitated saline contrast echocardiography result. Methods: We retrospectively recruited participants with comprehensive dementia evaluations, an agitated saline study, and brain imaging. The participants were classified into two groups according to WMH-distributions: dWMH and dpWMH (mainly periventricular WMH with or without deep WMH.) We hypothesized that dWMH is more likely associated with embolism, whereas dpWMH is associated with small-vessel diseases. We compared the clinical characteristics, WMH-distributions, and positive rate of agitated saline studies between the two groups. Results: Among 90 participants, 27 and 12 met the dWMH and dpWMH criteria, respectively. The dWMH-group was younger (62.2±7.5 vs. 78.9±7.3, p<0.001) and had a lower prevalence of hypertension (29.6% vs. 75%, p=0.008), diabetes mellitus (3.7% vs. 25%, p=0.043), and hyperlipidemia (33.3% vs. 83.3%, p=0.043) than the dpWMH-group. Regarding deep white matter lesions, the number of small lesions (<3 mm) was higher in the dWMH-group(10.9±9.7) than in the dpWMH-group (3.1±6.4) (p=0.008), and WMH was predominantly distributed in the border-zones and corticomedullary areas. Most importantly, the positive agitated saline study rate was higher in the dWMH-group than in the dpWMH-group (81.5% vs. 33.3%, p=0.003). Conclusions: The dWMH-group with younger participants had fewer cardiovascular risk factors, showed more border-zone-distributions, and had a higher agitated saline test positivity rate than the dpWMH-group, indicating that corticomedullary or deep WMH-distribution with minimal periventricular WMH suggests embolic etiologies.

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