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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background and Purpose White matter hyperintensities (WMH) are frequently observed on MRI in ischemic stroke patients as well as in normal elderly individuals. Besides the progression of WMH, the regression of WMH has been rarely reported. Thus, we aimed to investigate how WMH change over time in patients with ischemic stroke, particularly focusing on regression.
Methods We enrolled ischemic stroke patients who underwent brain MRI more than twice with at least a 6 month time-interval. Based on T2-weighted or FLAIR MRI, WMH were visually assessed, followed by semiautomatic volume measurement. Progression or regression of WMH change was defined when 0.25 cc increase or decrease was observed and it was also combined with visible change. A statistical analysis was performed on the pattern of WMH change over time and factors associated with change.
Results A total of 100 patients were enrolled. Their age (mean±SD) was 67.5±11.8 years and 63 were male. The imaging time-interval (mean) was 28.0 months. WMH progressed in 27, regressed in 9 and progressed in distinctive regions and regressed in others in 5 patients. A multiple logistic regression model showed that age (odds ratio[OR] 2.51, 90% confidence interval[CI] 1.056-5.958), male gender (OR 2.957, 95% CI 1.051-9.037), large vessel disease (OR 1.955, 95% CI 1.171-3.366), and renal dysfunction (OR 2.900, 90% CI 1.045-8.046) were associated with progression. Regarding regression, no significant factor was found in the multivariate analysis.
Conclusions In 21.5% of ischemic stroke patients, regression of WMH was observed. WMH progression was observed in a third of ischemic stroke patients.
목차
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참고문헌 (16)
참고문헌 신청
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Trial of Org 10172 in Acute Stroke Treatment /
Debette S / 2010 / The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis / BMJ 341 : c3666 ~
Durand-Birchenall J / 2012 / Attenuation of brain white matter lesions after lacunar stroke / Int J Prev Med 3 : 134 ~ 138
Enzinger C / 2007 / Progression of cerebral white matter lesions -- clinical and radiological considerations / J Neurol Sci 257 : 5 ~ 10
Fazekas F / 1987 / MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging / AJR Am J Roentgenol 149 : 351 ~ 356
Debette S / 2010 / The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis / BMJ 341 : c3666 ~
Durand-Birchenall J / 2012 / Attenuation of brain white matter lesions after lacunar stroke / Int J Prev Med 3 : 134 ~ 138
Enzinger C / 2007 / Progression of cerebral white matter lesions -- clinical and radiological considerations / J Neurol Sci 257 : 5 ~ 10
Fazekas F / 1987 / MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging / AJR Am J Roentgenol 149 : 351 ~ 356
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