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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Lacunar infarcts/lacunes, white matter hyperintensities (WMH), and cerebral microbleeds (CMBs) are considered various manifestations of cerebral small vessel disease (SVD). Since the exact mechanisms of these manifestations differ, their associated risk factors differ. High blood pressure is the most consistent risk factor for all of these manifestations. However, a “J curve” phenomenon in terms of blood pressure probably exists for WMH. The association between cholesterol levels and lacunar infarcts/lacunes or WMH was less consistent and sometimes conflicting; a low cholesterol level probably increases the risk of CMBs. Homocysteinemia appears to be associated with WMH. It is noteworthy that the risk factors profile may also differ between different lacunar patterns and CMBs located at different parts of the brain. Thrombolysis, antihypertensives, and statins are used to treat patients with symptomatic lacunar infarction, just as in those with other stroke subtypes. However, it should be remembered that bleeding risks increase in patients with extensive WMH and CMBs after thrombolysis therapy. According to the Secondary Prevention of Small Subcortical Strokes trial results, a blood pressure reduction to <130 mmHg is recommended in patients with symptomatic lacunar infarction. However, an excessive blood pressure decrease may induce cognitive decline in older patients with extensive WMH. Dual antiplatelet therapy (aspirin plus clopidogrel) should be avoided because of the excessive risk of intracerebral hemorrhage. Although no particular antiplatelet is recommended, drugs such as cilostazol or triflusal may have advantages for patients with SVD since they are associated with less frequent bleeding complications than aspirin
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참고문헌 (23)
참고문헌 신청
Altmann-Schneider I / 2011 / Cerebral microbleeds are predictive of mortality in the elderly / Stroke 42 : 638 ~ 644
Arauz A / 2003 / Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases /
Bakker SL / 1999 / Cerebral vasomotor reactivity and cereb
Bezerra DC / 2012 / Risk factors for lacune subtypes in the atherosclerosis risk in communities (aric) study / Neurology 78 : 102 ~ 108
Boiten J / 1993 / Two clinically distinct lacunar infarct entities? A hypothesis / Stroke 24 : 652 ~ 656
Arauz A / 2003 / Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases /
Bakker SL / 1999 / Cerebral vasomotor reactivity and cereb
Bezerra DC / 2012 / Risk factors for lacune subtypes in the atherosclerosis risk in communities (aric) study / Neurology 78 : 102 ~ 108
Boiten J / 1993 / Two clinically distinct lacunar infarct entities? A hypothesis / Stroke 24 : 652 ~ 656
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