지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 196 - 207 (12page)
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We made fusion protein of fastatin and FIII 9-10, termed simultaneously with αvβ3 and α5β1 integrins, both playing important roles in tumor angiogenesis. T-CAM can serve as a cel adhesion substrate mediating adhe-sion and migration of endothelial cells in αvβ3 and α5β1 integrin-dependent manner. T-CAM showed pro-nounced anti-angiogenic activities such as inhibition liferation, and induction of endothelial cell apoptosis. T-CAM also inhibited angiogenesis and tumor growth in mouse xenograft model. The anti-angiogenic and anti-tumoral activity of molecule like fastatin could be improved by fusing it with integrin-recognizing cell adhesion domain from other distinct proteins. The strategy of combining two distinct anti-angiogenic molecules or cell adhesion domains could facilitate designing improved anticancer agent of therapeutic value.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Alessi P / 2004 / Molecular targeting of angiogenesis / Biochim Biophys Acta 1654 : 39 ~ 49
Alghisi GC / 2006 / Vascular integrins in tumor angiogenesis: mediators and therapeutic targets / Endothelium 13 : 113 ~ 35
Bicknell R / 2004 / Novel angiogenic signaling pathways and vascular targets / Annu Rev Pharmacol Toxicol 44 : 219 ~ 38
Folkman J / 2002 / Role of angiogenesis in tumor growth and metastasis / Semin Oncol 29 : 15 ~ 8
Grant RP / 1997 / Structural requirements for biological activities of the ninth and tenth FIII domains of human fibronectin / J Biol Chem 272 : 6159 ~ 66
Alghisi GC / 2006 / Vascular integrins in tumor angiogenesis: mediators and therapeutic targets / Endothelium 13 : 113 ~ 35
Bicknell R / 2004 / Novel angiogenic signaling pathways and vascular targets / Annu Rev Pharmacol Toxicol 44 : 219 ~ 38
Folkman J / 2002 / Role of angiogenesis in tumor growth and metastasis / Semin Oncol 29 : 15 ~ 8
Grant RP / 1997 / Structural requirements for biological activities of the ninth and tenth FIII domains of human fibronectin / J Biol Chem 272 : 6159 ~ 66
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