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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 191 - 195 (5page)
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초록· 키워드
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es from the blood into peripheral tissues is a central feature of immune surveillance, but also contributes to the patho-genesis of inflammatory and autoimmune diseases. Integrins are a family of adhesion and signaling molecules made up of paired α and β subunits, and the integrin α4β1 plays a prominent role in the trafficking of mononuclear leukocytes. We have previously described the direct interaction of the signaling adaptor molecule paxillin with the cy-toplasmic domain of the α4 integrin subunit. This interaction is critical for α4β1 integrin dependent cell adhesion under shear flow conditions as it skeleton. Furthermore, the α4-paxillin interaction is required for effective α4β1 dependent leukocyte migration and does so through the temporal and spatial regulation of the small GTPase Rac. These findings make the α4-paxillin interaction a poten-tially attractive therapeutic target in controlling leukocyte trafficking.
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참고문헌 (29)
참고문헌 신청
/ / Talin binding to integrin be-
/ / Traffic signals for lymphocyte recirculation and leukocyte emigration : 301 ~ 14
/ / steps to specificity and diversity : 1033 ~
/ 1995 / Specialized functional properties of the integrin alpha 4 cytoplasmic domain 6 : 661 ~ 74
/ 1995 / The integrin VLA-4 supports tethering and rolling in flow on VCAM-1 128 : 1243 ~ 53
/ / Traffic signals for lymphocyte recirculation and leukocyte emigration : 301 ~ 14
/ / steps to specificity and diversity : 1033 ~
/ 1995 / Specialized functional properties of the integrin alpha 4 cytoplasmic domain 6 : 661 ~ 74
/ 1995 / The integrin VLA-4 supports tethering and rolling in flow on VCAM-1 128 : 1243 ~ 53
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