지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 194 - 200 (7page)
이용수
초록· 키워드
오류제보하기
Integrins are heterodimeric glycoproteins that havebeen found to undergo dynamic temporal and spa-tial changes in the endometrium during the men-strual cycle and in early pregnancy. Specificity ofintegrins is known to be different in human endome-trial stromal cells and decidual cells. These shifts ofintegrins suggested to play an important role inembryo implantation and can be modulated byprogesterone, cAMP derivatives, and cytokines. Themechanisms of decidualization and its precise phys-iological role are still not clearly understood and invitro systems could provide an alternative that over-comes limitations of studying such complex biolog-ical phenomena in vivo at the time of implantation.This study was undertaken to establish an in vitromodel system for human decidualization using 8-bromo-cAMP and to investigate the characteristicsof stromal integrin expression in vitro by 8-Br-cAMP.Endometrial stromal cells were isolated and cul-tured, and then were induced to decidualize by 0.5mM 8-Br-cAMP for 15 days. Immunofluorescencestaining and flow cytometric analyses of the integrinsubunits ( a1, a4, a5, a6, b1 and avb3) were per-formed at day 9. In the presence of 8-Br-cAMP, thestaining intensity of avb3 was significantly higherthan control and measurements for a1, a4, a5, a6,and b1 were similar. Immunofluorescent localizationof the integrins reflected the diferences obtainedfrom the flow cytometric analyses described above.In summary, the expresion of avb3 integrin increasedin stromal cells in vitro decidualized by 8-Br-cAMPand this up-regulation of avb3 integrin expressionduring decidualization might influence on humanimplantation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Integrins
한국동물학회 뉴스레터
1999 .01
-
CD98 activation increases surface expression and clusteringof β1 integrins in MCF-7 cells through FAK/Src- andcytoskeleton-independent mechanisms
Experimental and Molecular Medicine
2008 .01
-
Expression of integrins, cyclooxygenases and matrix metalloproteinases in three-dimensional human endometrial cell cultrue system
Experimental and Molecular Medicine
2002 .01
-
섬유아세포에서 한탄바이러스 감염시 α₅β₁Integrin의 역할
The Journal of the Korean Society for Microbiology
1997 .04
-
높은 cAMP 농도에서 cAMP 수용성 단백질의 열 안정화
생명과학회지
2003 .10
-
Inhibition of pRB Phosphorylation and Induction of p21WAF1/CIP1 Occur During cAMP-induced Growth Arrest in Human Neuroblastoma Cells
생명과학회지
2003 .10
-
Benzoic Acid Enhances Embryo Implantation through LIF-Dependent Expression of Integrin αVβ3 and αVβ5
Journal of Microbiology and Biotechnology
2017 .01
-
Integrin α5β1-Ang1/Tie2 receptor cross-talk regulates brain endothelial cell responses following cerebral ischemia
Experimental and Molecular Medicine
2018 .01
-
T-CAM, a fastatin-FIII 9-10 fusion protein, potently enhancesanti-angiogenic and anti-tumor activity via αvβ3 and α5β1integrins
Experimental and Molecular Medicine
2008 .01
-
Modulation of Thr-Phosphorylation of Integrin 1 during Muscle Differentiation
한국동물학회 학술대회
2001 .01
-
The role of the α4 integrin-paxillin interaction in regulating leukocyte trafficking
Experimental and Molecular Medicine
2006 .01
-
배양중인 개구리 여포의 cAMP 흡수와 분해
동물학회지
1991 .01
-
The role of stromal cells in cancer cell invasion : A cell-mechanics model
한국산업응용수학회 학술대회 논문집
2012 .05
-
Stable Expression of Bovine Integrin Beta-6 Increases Susceptibility of Goat Kidney Cell Line to Foot-and-mouth Disease Virus
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .03
-
Inhibition of Transfer Infection of Epstein-Barr Virus to Epithelial Cells by Integrin β6 siRNA
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2012 .12
-
Human cytomegalovirus 증식에 미치는 cAMP의 영향
미생물학회지
1993 .02
-
In vivo characterization of the integrin b3 as a receptor for Hantaan virus cellular entry
Experimental and Molecular Medicine
2005 .01
-
Transforming Growth Factor-$\beta_{2}$ Promotes the Integrin $\alpha_{5}\beta_{1}$ Expression at Condensation Period of Chondrogenic Differentiation in vitro.
한국동물학회 학술대회
1994 .01
-
동물학 논단
한국동물학회 뉴스레터
2000 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0