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논문 기본 정보

자료유형
학술저널
저자정보
Heo, Jee-In (Department of Biochemistry, College of Medicine, Hallym University) Oh, Soo-Jin (Department of Biochemistry, College of Medicine, Hallym University) Kho, Yoon-Jung (Institute of Natural Medicine, College of Medicine, Hallym University) Kim, Jeong-Hyeon (Department of Biochemistry, College of Medicine, Hallym University) Kang, Hong-Joon (Department of Biochemistry, College of Medicine, Hallym University) Park, Seong-Hoon (Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH) Kim, Hyun-Seok (Molecular Radiation Oncology, Radiation Oncology Branch, Center for Cancer Research, NCI, NIH) Shin, Jong-Yeon (Genomic Medicine Institute, Medical Research Center, Seoul National University) Lee, Sung-Young (Department of Biochemistry, College of Medicine, Hallym University) Kim, Min-Ju (Department of Anatomy and Neurobiology, College of Medicine, Hallym University) Min, Bon-Hong (Department of Pharmacology, College of Medicine, Korea University) Kim, Sung-Chan (Department of Biochemistry, College of Medicine, Hallym University) Park, Jae-Bong (Department of Biochemistry, College of Medicine, Hallym University) Kim, Jae-Bong (Department of Biochemis) Lee, Jae-Yong
저널정보
한국통합생물학회 Animal cells and systems Animal cells and systems 제14권 제4호
발행연도
2010.1
수록면
261 - 266 (6page)

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PC12 cells were differentiated into the cells of chromaffin phenotype by butyrate treatment. Cells were aggregated and formed tight cell adhesion. To investigate the molecular change in this differentiation, we examined expression levels of cell adhesion proteins and extracellular proteins during butyrate induced-differentiation of PC12 cells. Integrin ${\beta}1$, integrin ${\alpha}7$, E cadherin, VCAM, collagen-I, fibronectin, desmoglein and connexin were increased during differentiation. The levels of clusterin and secreted clusterin were also increased. These increased levels of cell adhesion proteins and extracellular proteins appear to induce cell aggregation and tight cell adhesion. The levels of p21, p27 and p16 were increased probably because of differentiation-related growth arrest during differentiation. Prolonged incubation of butyrate up to 1 day was required for differentiation. Signal transduction pathways for this differentiatiom could not be identified since various inhibitors had no effect. The results showed that butyrateinduced differentiation of PC12 cells to chromaffin cells involves tight cell adhesion and induction of extracellular proteins and cell adhesion proteins.
#butyrate #PC12 #differentiation #chromaffin cells #cell adhesion proteins

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참고문헌 (18)

참고문헌 신청
Allfrey VG / 1964 / Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis / Proc Natl Acad Sci U S A. :786~794 google schola Byrd JC / 1987 / Differentiation of PC12 pheochromocytoma cells by sodium butyrate / Brain Res. 428:151~155 google schola Byrd JC / 1987 / Two types of transglutaminase in the PC12 pheochromocytoma cell line. Stimulation by sodium butyrate / J Biol Chem. 262:11699~11705 google schola Byrd JC / 1987 / Proenkephalin gene expression in the PC12 pheochromocytoma cell line: stimulation by sodium butyrate / Endocrinology 121:1299~1305 google schola Davie JR. / 2003 / Inhibition of histone deacetylase activity by butyrate / J Nutr. 133:2485S~2493S google schola

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